Acute Coronary Syndrome Clinical Trial
Official title:
Markers of Vascular Aging and Coronary Syndrome
Atherosclerosis and aging are associated to the raise of biochemical alterations of proteins
grouped under the name of " non-enzymatic post-translational modifications ". They often
correspond to the irreversible binding of glucose or other oses (glycation) or urea
derivatives (carbamylation) on proteins and lead to the formation of complex compounds
(post-translational modifications derived products, PTMD) that can accumulate in tissues and
be responsible for deleterious effects. The specific role of these compounds in the
pathophysiology of aging and atherosclerosis remains unknown, as are the molecular and
cellular mechanisms implicated.
This project is based on the hypothesis that non-enzymatic post-translational modifications
may cause changes in the genesis of complication of coronary atherosclerosis and that PTMD
could therefore constitute relevant biomarkers in this specific clinical situation.
To explore these potential new biomarkers, the investigators designed a study in patients
having experienced an acute coronary syndrome and followed during a year. The concentrations
of PTMD assayed at 0, 1, 3, 12 months, will be correlated to clinical (severity and
evolution) and paraclinical (cutaneous autofluorescence) data and the effect of cardiac
rehabilitation will be assessed.
This should help to identify new (and non-traditional) biomarkers of coronary heart disease
and determine some of the implicated pathophysiological mechanisms.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05846893 -
Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease
|
N/A | |
| Recruiting |
NCT06013813 -
Conventional vs. Distal Radial Access Outcomes in STEMI Patients Treated by PCI
|
N/A | |
| Recruiting |
NCT05412927 -
AngelMed Guardian® System PMA Post Approval Study
|
||
| Completed |
NCT02750579 -
Early or Delayed Revascularization for Intermediate and High-risk Non ST-elevation Acute Coronary Syndromes?
|
N/A | |
| Completed |
NCT04102410 -
Assessing Force-velocity Profile: an Innovative Approach to Optimize Cardiac Rehabilitation in Coronary Patients
|
N/A | |
| Enrolling by invitation |
NCT03342131 -
Serum Concentration of Wnt2 and Wnt4 in Patients With Acute Coronary Syndrome
|
N/A | |
| Recruiting |
NCT01218776 -
International Survey of Acute Coronary Syndromes in Transitional Countries
|
||
| Enrolling by invitation |
NCT04676100 -
International CR Registry
|
||
| Completed |
NCT03590535 -
5th Generation cTnT in ED ACS
|
||
| Recruiting |
NCT05437900 -
INSIGHTFUL-FFR Clinical Trial
|
Phase 4 | |
| Completed |
NCT05551429 -
Factors Related to Participation in Cardiac Rehabilitation in Patients With Acute Coronary Syndrome
|
||
| Terminated |
NCT04316481 -
IDE-ALERTS Continued Access Study
|
N/A | |
| Active, not recruiting |
NCT04475380 -
Complex All-comers and Patients With Diabetes or Prediabetes, Treated With Xience Sierra Everolimus-eluting Stents
|
||
| Not yet recruiting |
NCT04852146 -
Electronic Feedback for Data Restitution and Valorization to the Emergency Teams in Aquitaine.
|
||
| Active, not recruiting |
NCT02892903 -
In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?
|
N/A | |
| Not yet recruiting |
NCT02871622 -
BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM
|
N/A | |
| Completed |
NCT02944123 -
Half Dose of Prasugrel and Ticagrelor in Acute Coronary Syndrome (HOPE-TAILOR)
|
Phase 3 | |
| Completed |
NCT04077229 -
Piloting Text Messages to Promote Positive Affect and Physical Activity
|
N/A | |
| Active, not recruiting |
NCT02922140 -
The Impact of Pharmaceutical Care Practice on Patients in Cardiac Rehabilitation Unit
|
N/A | |
| Terminated |
NCT02620202 -
Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain
|