Acute Coronary Syndrome Clinical Trial
Official title:
Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Acute Coronary Syndrome
The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for suspected ACS patients at the emergency department (ED) and intensive care unit (ICU).
The present study is a single-center, prospective diagnostic study among patients presenting
to the ED or ICU within 24 h of onset of chest pain suggestive of suspected ACS.
We propose to construct the biobank of ACS and evaluate the potential diagnostic value of
circulating microRNAs compared with cTnI for suspected ACS patients. All the patients are to
be followed up for 6 months. Final diagnosis was made by an expert panel cardiologist, based
on all available clinical information including cTnI measurements, ECG, coronary angiography,
cardiac exercise tests and information from hospital discharge letters.
The concentrations of microRNAs will be evaluated by quantitative reverse transcription PCR,
using highly specific primers and hybridization probes.
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