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Acid-Base Imbalance clinical trials

View clinical trials related to Acid-Base Imbalance.

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NCT ID: NCT04597983 Completed - Oxidative Stress Clinical Trials

Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists

Start date: September 22, 2018
Phase: N/A
Study type: Interventional

This clinical study evaluates the effect of 500 mg of 2S-hesperidin for 8 weeks on performance (power generated in different metabolic zones), body composition (fat and muscle mass) and biochemical (antioxidant, inflammatory status) and metabolic (capillary blood in finger) markers in amateur cyclists. Our hypothesis is that chronic intake of 2S-hesperidin can improve performance (maximum power generated). To justify this hypothesis, we measured the parameters mentioned above, which could establish a cause-effect relationship between 2S-hesperidin intake and possible yield improvement.

NCT ID: NCT03966664 Recruiting - Sepsis Clinical Trials

Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients

Start date: June 3, 2019
Study type: Observational

Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.

NCT ID: NCT03507062 Recruiting - Acid-Base Imbalance Clinical Trials

Effect of Crystalloids With Different SID on pH, and Urinary Electrolytes During General Anesthesia

Start date: December 10, 2017
Phase: Phase 4
Study type: Interventional

The present study will investigate variations in acid base equilibrium caused by the administration of four different crystalloids with increasing strong ion difference (0.9% saline, Ringer's lactate, Ringer's acetate, plasmalyte-like solution) in patients during general anesthesia. The same crystalloid will be administered throughout the surgery. In order to assess the effect of hemodilution, every patient will receive two fluid boli with different volumes of the same solution. pH and strong ion variations, togher with the renal response to acid base disturbances, will be analysed.

NCT ID: NCT03503214 Completed - Acid-Base Imbalance Clinical Trials

Non Carbonic Buffer Power of Critical Ill Patients With Sepsis

Start date: March 7, 2018
Study type: Observational

Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment. The human organism is protected against acid-base disorders by several compensatory mechanisms that minimize pH variations in case of blood variations in carbon dioxide content. The aim of the present study is to quantify the buffer power, i.e. the capacity to limit pH variations in response to carbon dioxide changes, in critically ill septic patients and compare these results with data collected from healthy volunteers.

NCT ID: NCT03496311 Recruiting - Pregnancy Clinical Trials

Cerebrospinal Acid-base in Pregnant and Non-pregnant Fertile Women

Start date: April 13, 2018
Study type: Observational

The third trimester of pregnancy is typically characterized by the development of a marked respiratory alkalosis. The possible role of pregnancy-induced variations of cerebrospinal fluid (CSF) acid-base characteristics on the development of hypocapnic alkalosis is still unknown. Aim of this study is to characterize, according to Stewart's approach, the acid-base equilibrium of CSF and arterial plasma of pregnant women and compare the results with data obtained from fertile, non-pregnant women.

NCT ID: NCT03142464 Completed - Clinical trials for Postoperative Nausea

Intravenous Fluids After Laparoscopic Cholecystectomy

Start date: July 1, 2015
Phase: N/A
Study type: Interventional

Perioperative intravenous fluid (IV) administration has been the standard procedure since 1832 and, is a widely used practice sometimes under inadequate criteria. The present work aims at verifying the clinical need that justifies the common IV fluid prescription on the postoperative (PO) period in patients undergoing videolaparoscopic cholecystectomy (CVL) elective.

NCT ID: NCT02980770 Recruiting - Clinical trials for Obstructive Sleep Apnea

Postoperative Complications in Patients With Obesity Hypoventilation Syndrome

Start date: November 2016
Phase: N/A
Study type: Observational

Obstructive sleep apnea (OSA) and Obesity-Hypoventilation Syndrome (OHS) are common conditions in obesity, which may influence the prognosis in patients undergoing surgery. There is a need for simple screening tools to identify such patients at high risk. The current multicenter observational study aims to investigate occurrence of OSA and OHS in obese individuals undergoing elective abdominal surgery and further address its impact on perioperative and postoperative complications.

NCT ID: NCT02691676 Completed - Acid Base Imbalance Clinical Trials

Perioperative Fluid Therapy With Balanced Crystalloids

Start date: January 2014
Phase: Phase 3
Study type: Interventional

Introduction: The strategy of perioperative fluid therapy has an important impact not only on the circulating volume and perfusion of organs and tissues but also on the patient's internal environment. The study aimed at comparing the effects of perioperatively administered balanced crystalloid infusion solutions containing different amounts of metabolizable anions on homeostasis. Methods: In the prospective randomized study, patients were assigned to Plasmalyte (PL) and Ringerfundin (RF) Groups after their postoperative transfer to an intensive care unit (ICU). The infusion solutions were parenterally administered at 1000 mL/6 hours. Arterialized capillary blood was sampled at the time of transfer to the ICU (Time 0), and again at 2 hours and 6 hours from Time 0. The collected blood was tested for blood gas parameters using the Astrup method.

NCT ID: NCT01820702 Completed - Body Weight Changes Clinical Trials

Short Term Bed Rest Study: Evaluation of the Use of Artificial Gravity, Induced by Short-arm Centrifugation

Start date: November 2010
Phase: N/A
Study type: Interventional

Randomized cross-over design with 10 male subjects and 3 campaigns to test whether the negative effects of bed rest (6º head-down tilt) on the various systems of the body and the consequences to health of simulated weightlessness can be counteracted by the use of a defined training programme.

NCT ID: NCT01509456 Completed - Body Weight Changes Clinical Trials

The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation

Start date: February 2010
Phase: N/A
Study type: Interventional

Mainly due to the absence of gravitational forces in weightlessness, astronauts suffer from an increased bone loss- negatively affecting health and vitality during a mission. The development of effective countermeasures to this loss includes many different aspects like sports but also nutrition. Alkaline salts, abundant in fruits and vegetables, have shown to have positive effects on markers of bone turnover of postmenopausal women but also men and younger adults. With the current study the effects of a potassium bicarbonate supplementation added to a standardised, strictly controlled, definite diet of healthy, young men, should be verified within 21 days of 6°- HDT- Bedrest- the gold standard of simulating weightlessness within earthbound conditions.