Comprehensive Esophageal Diagnostics Study

Status Recruiting

Clinical Trial Summary

The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that utilizes impedance planimetry) after pharmacologic challenge. A better understanding of achalasia will allow intervention at an earlier stage.

Clinical Trial Description

Achalasia is a disease characterized by inadequate opening of the lower esophageal sphincter. Achalasia is presumed to be due to neuronal dysfunction (active), however there are other variables such as muscle layer fibrosis (passive) that may contribute, particularly in milder or earlier achalasia variants. A new technology, impedance planimetry, may be able to measure active vs passive features of the lower esophageal sphincter (LES). The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that utilizes impedance planimetry) after pharmacologic challenge. A better understanding of achalasia will allow intervention at an earlier stage. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04641702
Study type	Interventional
Source	Emory University
Contact	Anand Jain, MD
Phone	404-778-3184
Email	anand.jain@emory.edu
Status	Recruiting
Phase	Phase 4
Start date	March 17, 2021
Completion date	December 2024

View Details

See also
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