Clinical Trials Logo

Achalasia clinical trials

View clinical trials related to Achalasia.

Filter by:

NCT ID: NCT03228758 Recruiting - Achalasia Clinical Trials

Anterior Orientation vs Posterior Orientation in Per Oral Endoscopic Myotomy POEM for the Treatment of Achalasia

Start date: July 24, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the safety and efficacy of the anterior versus posterior myotomy technique in Per Oral Endoscopic Myotomy (POEM) for the treatment of Achalasia. The primary efficacy outcome is periprocedural pain requiring the use of narcotics. The secondary outcomes focus on safety which includes technical procedure duration time; tunneling time, myotomy time, and closure time; incidence of mucosotomy (transmural and non-transmural injury), capnoperitoneum, and the postoperative sequelae of gastrointestinal reflux disease (GERD). Periprocedural pain data collection will include post POEM procedure pain scores, administrations of analgesia until discharge. The final analysis will focus on determining whether there is a statistically significant difference in the amount and severity of pain in the Anterior versus Posterior myotomy subject populations. Additional analysis will be the collection of analgesic type (narcotic versus non-narcotic), dosage, frequency, and duration of treatment from post POEM procedure in the endoscopy recovery suite until the subjects are discharged.

NCT ID: NCT03123835 Enrolling by invitation - Achalasia Clinical Trials

Outcome Analysis of POEM and Endoluminal Therapies

Start date: March 2016
Phase: N/A
Study type: Interventional

Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.

NCT ID: NCT03063463 Recruiting - Achalasia Clinical Trials

Mechanisms of Weight Loss in Patients Diagnosed With Achalasia

Start date: February 15, 2017
Phase: N/A
Study type: Observational

Currently there are no existing data to determine why some achalasia patients lose weight while others do not. The purpose of this study is to gather data from patients diagnosed with achalasia to determine if differences may be identified between those who lose weight and those who do not that would help us better understand the mechanism of weight loss in this population.

NCT ID: NCT02989883 Recruiting - Achalasia Clinical Trials

Clinical Outcomes of Peroral Endoscopic Myotomy

Start date: October 2016
Phase: N/A
Study type: Interventional

Esophageal outflow obstruction is characterized by failure to relax the lower esophageal sphincter (LES), resulting in impaired flow of ingested food into the stomach. The subsequent stasis of ingested food leads to symptoms of dysphagia, regurgitation, chest pain, and weight loss. The core objective of the treatment of esophageal outflow obstruction is to disrupt the LES and reduce its pressure to allow esophageal emptying. Therapeutic options include pharmacologic therapy, Botulinum toxin injection, pneumatic balloon dilation, and surgical myotomy with partial fundoplication. In addition, peroral endoscopy myotomy (POEM) has recently been introduced as a minimally invasive treatment, but there have a few studies regarding long-term outcomes. The aim of this study is to evaluate clinical outcomes of POEM for esophageal outflow obstruction.

NCT ID: NCT02931565 Recruiting - Achalasia Clinical Trials

Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia

Start date: February 2016
Phase: Phase 2
Study type: Interventional

The objectives of this study are as follows: In patients with primary Type I or II Achalasia, following a single 5-mg dose of IW-1701, - To assess the safety and tolerability - To determine the effects on measures of esophageal function by high-resolution impedance manometry (HRIM) - To determine the pharmacokinetic (PK) parameters, Cmax, Tmax, and AUClast

NCT ID: NCT02770859 Enrolling by invitation - Achalasia Clinical Trials

Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository

POEM
Start date: October 2014
Phase: N/A
Study type: Observational [Patient Registry]

POEM (Per-Oral endoscopic myotomy (creating a muscle [esophagus] opening), an incision-less (no cutting of the surface of the body) endoscopic procedure, is an effective non-surgical alternative to release the muscle & sphincter of the LES for the treatment of achalasia.

NCT ID: NCT02606578 Recruiting - Achalasia Clinical Trials

Achalasia Patient Reported Outcomes

Start date: October 2015
Phase: N/A
Study type: Observational

Patients that are either scheduled to undergo or have undergone an achalasia procedure at the Mayo Clinic Rochester are asked to participate. The purpose of this study is to gather information and determine if one of these procedures is superior to the other.

NCT ID: NCT02482337 Recruiting - Achalasia Clinical Trials

Per-Oral Endoscopic Myotomy for Esophageal Swallowing Disorders

POEM
Start date: June 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to show that the Per-Oral Endoscopic Myotomy (POEM) procedure is an effective treatment for people with achalasia.

NCT ID: NCT02454335 Active, not recruiting - Achalasia Clinical Trials

POEM Anterior Versus Posterior Approach

Start date: January 2015
Phase: N/A
Study type: Interventional

Per-oral endoscopic myotomy (POEM) is an incisionless procedure used to treat esophageal achalasia, performed by GI endoscopist without cutting any surface of the human body. The main constituent of the procedure is the myotomy part, through which the endoscopist cuts the muscle fibers in the submucosa. Since this procedure is completely new to the area of treatment of achalasia, it is unknown whether a posterior or an anterior myotomy is better in relieving the symptoms. Thenceforth, this study aims at randomizing patients with achalasia presenting for POEM to getting either the posterior or the anterior myotomy. Patients will be followed up for symptoms and complications; data will be extracted and the appropriate analysis will be employed to determine if there is any difference of outcome between the two techniques of myotomy.

NCT ID: NCT02434991 Not yet recruiting - Achalasia Clinical Trials

Sensorimotor Dysfunction in Achalasia

Start date: October 2016
Phase: N/A
Study type: Interventional

This study is being done to assess the esophageal muscle (swallowing tube) in patients with and without achalasia to further understand and help direct the treatment for patients with achalasia.