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Achalasia clinical trials

View clinical trials related to Achalasia.

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NCT ID: NCT03123835 Enrolling by invitation - Achalasia Clinical Trials

Outcome Analysis of POEM and Endoluminal Therapies

Start date: March 2016
Phase: N/A
Study type: Interventional

Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.

NCT ID: NCT03063463 Recruiting - Achalasia Clinical Trials

Mechanisms of Weight Loss in Patients Diagnosed With Achalasia

Start date: February 15, 2017
Phase: N/A
Study type: Observational

Currently there are no existing data to determine why some achalasia patients lose weight while others do not. The purpose of this study is to gather data from patients diagnosed with achalasia to determine if differences may be identified between those who lose weight and those who do not that would help us better understand the mechanism of weight loss in this population.

NCT ID: NCT02989883 Recruiting - Achalasia Clinical Trials

Clinical Outcomes of Peroral Endoscopic Myotomy

Start date: October 2016
Phase: N/A
Study type: Interventional

Esophageal outflow obstruction is characterized by failure to relax the lower esophageal sphincter (LES), resulting in impaired flow of ingested food into the stomach. The subsequent stasis of ingested food leads to symptoms of dysphagia, regurgitation, chest pain, and weight loss. The core objective of the treatment of esophageal outflow obstruction is to disrupt the LES and reduce its pressure to allow esophageal emptying. Therapeutic options include pharmacologic therapy, Botulinum toxin injection, pneumatic balloon dilation, and surgical myotomy with partial fundoplication. In addition, peroral endoscopy myotomy (POEM) has recently been introduced as a minimally invasive treatment, but there have a few studies regarding long-term outcomes. The aim of this study is to evaluate clinical outcomes of POEM for esophageal outflow obstruction.

NCT ID: NCT02931565 Recruiting - Achalasia Clinical Trials

Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type II Achalasia

Start date: February 2016
Phase: Phase 2
Study type: Interventional

The objectives of this study are as follows: In patients with primary Type II Achalasia, following a single 5-mg dose of IW-1701, - To assess the safety and tolerability - To determine the effects on measures of esophageal function by high-resolution impedance manometry (HRIM) - To determine the pharmacokinetic (PK) parameters, Cmax, Tmax, and AUClast

NCT ID: NCT02606578 Recruiting - Achalasia Clinical Trials

Achalasia Patient Reported Outcomes

Start date: October 2015
Phase: N/A
Study type: Observational

Patients that are either scheduled to undergo or have undergone an achalasia procedure at the Mayo Clinic Rochester are asked to participate. The purpose of this study is to gather information and determine if one of these procedures is superior to the other.

NCT ID: NCT02482337 Recruiting - Achalasia Clinical Trials

Per-Oral Endoscopic Myotomy for Esophageal Swallowing Disorders

POEM
Start date: June 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to show that the Per-Oral Endoscopic Myotomy (POEM) procedure is an effective treatment for people with achalasia.

NCT ID: NCT02454335 Active, not recruiting - Achalasia Clinical Trials

POEM Anterior Versus Posterior Approach

Start date: January 2015
Phase: N/A
Study type: Interventional

Per-oral endoscopic myotomy (POEM) is an incisionless procedure used to treat esophageal achalasia, performed by GI endoscopist without cutting any surface of the human body. The main constituent of the procedure is the myotomy part, through which the endoscopist cuts the muscle fibers in the submucosa. Since this procedure is completely new to the area of treatment of achalasia, it is unknown whether a posterior or an anterior myotomy is better in relieving the symptoms. Thenceforth, this study aims at randomizing patients with achalasia presenting for POEM to getting either the posterior or the anterior myotomy. Patients will be followed up for symptoms and complications; data will be extracted and the appropriate analysis will be employed to determine if there is any difference of outcome between the two techniques of myotomy.

NCT ID: NCT02434991 Not yet recruiting - Achalasia Clinical Trials

Sensorimotor Dysfunction in Achalasia

Start date: October 2016
Phase: N/A
Study type: Interventional

This study is being done to assess the esophageal muscle (swallowing tube) in patients with and without achalasia to further understand and help direct the treatment for patients with achalasia.

NCT ID: NCT02428959 Recruiting - Dysphagia Clinical Trials

Prospective Study to Assess the Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM)

Amyl Nitrite
Start date: June 2014
Phase: N/A
Study type: Interventional

This research is being done to see if a study drug called amyl nitrite can be helpful with diagnosing different disorders affecting the lower esophageal sphincter in patients with dysphagia (difficulty swallowing foods) undergoing high resolution esophageal manometry (HRM). Dysphagia may be one of the symptoms of a condition known as idiopathic achalasia. Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach. This affects the ability of the esophagus to move food toward the stomach. Pseudoachalasia is a secondary form of achalasia, which has very similar symptoms but is caused by different reasons. Because the treatments for achalasia and pseudoachalasia are different, it is important to correctly diagnose each condition. At this time, there is no way to distinguish the two with the current tests used at Johns Hopkins. Amyl nitrite relaxes vascular smooth muscle and has been studied previously as a potential means to separate achalasia from pseudoachalasia. Amyl nitrite is approved by the Food and Drug Administration (FDA) for the treatment of cardiac angina. It is not approved for use in motility testing and its use in this study is considered investigational. Investigators hope that the results from the proposed study could have significant clinical implications for patient management by helping doctors distinguish between achalasia and pseudoachalasia and allow them to choose appropriate treatment. Patients with dysphagia (difficulty swallowing foods) undergoing routinely scheduled high resolution esophageal manometry (HRM) may join this study.

NCT ID: NCT02314741 Completed - Achalasia Clinical Trials

Peroral Endoscopic Myotomy (POEM) for Esophageal Motility

POEM
Start date: May 2014
Phase: N/A
Study type: Interventional

The investigators wish to monitor the adoption of a new, incisionless approach to performing a Heller myotomy for the surgical treatment of achalasia. The method, the Peroral Endoscopic Myotomy (POEM), will provide less-invasive treatment for esophageal achalasia, ideally providing similar if not better outcomes (safety and efficacy) as the Heller myotomy. The investigators hope to enroll 10 patients with a clinical diagnosis of achalasia who meet inclusion criteria. The POEM procedure has been done in many hospitals without any research associated with it. Dr. Ginsberg, Dr. Chandrasekhara and Dr. Kochman will perform the procedures after being trained. Dr. Ginsberg has personally witnessed the performance of 10 POEM procedures and has performed in a swine model. The PI is credentialed to initiate POEM at HUP with the first case to be proctored by an experienced operator. The PI will then proctor the other adopters. The investigators would like to evaluate the safety of it and the effectiveness of it. The investigators will use their symptom scores and radiology tests pre- and post-POEM to evaluate effectiveness.