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Achalasia clinical trials

View clinical trials related to Achalasia.

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NCT ID: NCT04798547 Enrolling by invitation - Achalasia Clinical Trials

Short Vs Standard Length Myotomy in Achalasia

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

The objective of this randomized controlled trial (non-inferiority study) is to evaluate the outcomes of 4 cm short myotomy compared to the 8 cm standard length myotomy in Per-Oral Endoscopic Myotomy (POEM) for patients with achalasia. We hypothesize that a shorter myotomy with POEM will have the same clinical efficacy as standard length myotomy based on patient-reported Eckardt score with shorter procedure times and reduced complications.

NCT ID: NCT04770441 Not yet recruiting - Achalasia Clinical Trials

Transoral Incisionless Fundoplication in Post-POEM GERD

Start date: March 15, 2021
Phase:
Study type: Observational [Patient Registry]

POEM (per oral endoscopic myotomy) is effective for the treatment of swallowing disorders but can induce acid reflux. If acid reflux remains untreated in this situation, it can lead to significant problems. Thus, minimizing abnormal acid exposure after POEM is very important. Typically, this is done with acid suppression medications such as Prilosec or Nexium. However, long term acid suppression medication has been linked to possible long-term complications. Transoral incisionless fundoplication (TIF) has been approved for the treatment of reflux, but its use in reflux after POEM has not been investigated in detail. We hypothesize TIF will be able to decrease the amount of acid reflux in to the esophagus, thereby allowing patients to remain off of acid suppression medications. Once enrolled into the study, you will undergo the POEM procedure. 3 months after the procedure we will assess for abnormal reflux via questionnaires and diagnostic testing as part of the standard management post POEM. If there is evidence of abnormal reflux, the TIF procedure will be performed. 3 months after the TIF, you will have similar testing again to document resolution in abnormal acid reflux.You will be followed for 12 months as part of the study. If at the 3 month mark, there is no evidence of abnormal reflux, you will neither be placed on PPI nor undergo TIF and will be followed for 12 months to assess for abnormal reflux

NCT ID: NCT04752670 Not yet recruiting - Gastroparesis Clinical Trials

ConMed Beamer Study

Start date: March 31, 2021
Phase:
Study type: Observational [Patient Registry]

This is a prospective registry of all patients who endoscopic submucosal dissection (ESD), per-oral endoscopic myotomy (POEM) and gastric per-oral endoscopic myotomy (G-POEM) using ConMed Electrosurgical unit for submucosal Dissection at Baylor St Luke's Medical Center. Collected information includes; procedure technical success rate, duration, periprocedural complications and ease of use.

NCT ID: NCT04740437 Recruiting - Clinical trials for Gastroesophageal Reflux

Systematic IPP VS Symptomatic IPP in GERD Prevention After POEM for Achalasia. . A Comparative Retrospective Analysis

IPPOEM-Retro
Start date: January 1, 2017
Phase:
Study type: Observational

POEM is a minimally invasive endoscopic therapy that is highly efficacy in the treatment of achalasia of any type. POEM has an increased risk of GERD. Systematic PPI therapy has never been studied for the prevention of post-POEM GERD. The investigators wish to retrospectively compare patients who have received routine PPI therapy vs. patients who don't.

NCT ID: NCT04641702 Recruiting - Achalasia Clinical Trials

Comprehensive Esophageal Diagnostics Study

Start date: March 2021
Phase: Phase 4
Study type: Interventional

The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that utilizes impedance planimetry) after pharmacologic challenge designed to augment and remove the active component (edrophonium and atropine administration respectively) of LES tone. A better understanding of achalasia will allow intervention at an earlier stage, potentially with anti-fibrosis agents or anti-inflammatory agents and improve treatment outcomes.

NCT ID: NCT04640753 Recruiting - Achalasia Clinical Trials

Peroral Endoscopic Myotomy for the Treatment of Achalasia

Start date: February 6, 2019
Phase:
Study type: Observational

There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019 & a prospective chart review will be performed for patients who will undergo endoscopic procedures and POEM from 02/2019 - 06/2021

NCT ID: NCT04180241 Recruiting - Achalasia Clinical Trials

Development of Endoscopic Treatment for Achalasia

POEM
Start date: April 15, 2019
Phase: N/A
Study type: Interventional

Per Oral Endoscopic Myotomy (POEM); comparison of two surgical techniques division all the esophageal muscle layers versus division the inner circular muscle layer of the esophagus only.

NCT ID: NCT04177342 Not yet recruiting - Achalasia Clinical Trials

Post Operative Pain Control of POEM Procedure

Start date: January 1, 2020
Phase: Phase 4
Study type: Interventional

Peroral endoscopic myotomy (POEM) is a minimally invasive treatment for esophageal achalasia with a natural orifice transluminal endoscopic procedure and far less invasive than the standard surgical or laparoscopic Heller myotomy (LHM). Less is known about the postoperative pain after POEM and the minor surgery trauma, short length of stay may lead to underestimation of postoperative pain control. We tend to observe the pain status after the POEM surgery under the empirical treatment in our center, and find a proper intra-operative way of pain control to solve the post-operative pain and seek the possible influence factors of postoperative pain.

NCT ID: NCT04065516 Enrolling by invitation - Clinical trials for Gastroesophageal Reflux

ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia

ARAT
Start date: July 3, 2019
Phase: N/A
Study type: Interventional

The peroral endoscopic myotomy for the treatment of achalasia is associated with a higher incidence of gastroesophageal reflux disease compared with Heller's myotomy. Remodeling of the esophagogastric junction with hybrid argon plasma could decrease the passage of gastric or gastroduodenal content into the esophagus.

NCT ID: NCT04052581 Not yet recruiting - Clinical trials for Gastroesophageal Reflux Disease

Prospective Collection of Outcome Data Post POEM-TIF Procedure

Start date: May 2021
Phase:
Study type: Observational

Per Oral Endoscopic Myotomy has been established as a safe and effective treatment of Achalasia type I and II; however, it is limited by post-procedure gastroesophageal reflux. Transoral Incisionless Fundoplication (TIF) has been introduced as the endoscopic gold standard for anti-reflux procedure. Recently, combined POEM-TIF has been performed successfully as a standard of care treatment for patients with severe GER after POEM. We aim to study the safety and feasibility of performing POEM-TIF (POEM and TIF in the same endoscopic session). This study will also put the groundwork for a randomized clinical trial to further study the clinical outcome of the POEM-TIF procedure.