Clinical Outcomes of Peroral Endoscopic Myotomy

Status Recruiting

Clinical Trial Summary

Esophageal outflow obstruction is characterized by failure to relax the lower esophageal sphincter (LES), resulting in impaired flow of ingested food into the stomach. The subsequent stasis of ingested food leads to symptoms of dysphagia, regurgitation, chest pain, and weight loss. The core objective of the treatment of esophageal outflow obstruction is to disrupt the LES and reduce its pressure to allow esophageal emptying. Therapeutic options include pharmacologic therapy, Botulinum toxin injection, pneumatic balloon dilation, and surgical myotomy with partial fundoplication. In addition, peroral endoscopy myotomy (POEM) has recently been introduced as a minimally invasive treatment, but there have a few studies regarding long-term outcomes. The aim of this study is to evaluate clinical outcomes of POEM for esophageal outflow obstruction.

Clinical Trial Description

Prospective study ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02989883
Study type	Interventional
Source	Asan Medical Center
Contact	Hwoon-Yong Jung
Email	hyjung@amc.seoul.kr
Status	Recruiting
Phase	N/A
Start date	October 2016
Completion date	September 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01399476` - Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia	N/A
Recruiting	`NCT05326113` - The Effect of Physiotherapy on Post POEM Reflux	N/A
Recruiting	`NCT06044155` - redoPOEM : Failure of a First POEM
Terminated	`NCT02606578` - Achalasia Patient Reported Outcomes
Recruiting	`NCT01793922` - POEM Trial: Multi-center Study Comparing Endoscopic Pneumodilation and Per Oral Endoscopic Myotomy (POEM)	N/A
Recruiting	`NCT01302288` - Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia	Phase 2
Terminated	`NCT03875365` - Institutional Outcome Data From Per-oral Plication of the Esophagus
Enrolling by invitation	`NCT02770859` - Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository
Recruiting	`NCT05905016` - Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
Completed	`NCT01692106` - A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia	N/A
Completed	`NCT01405469` - Endoscopic Peroral Myotomy for Treatment of Achalasia	N/A
Completed	`NCT01402518` - Per-Oral Endoscopic Myotomy
Not yet recruiting	`NCT00790465` - Efficacy of Dark Chocolate in Achalasia Patients	Phase 1/Phase 2
Recruiting	`NCT01799967` - Minimally Invasive Surgery of the Gastro-esophageal Junction
Terminated	`NCT00604942` - vMII for Measurement of Oesophageal Bolus Transport and Reflux	N/A
Not yet recruiting	`NCT06042127` - POEM-F for Achalasia International Study	N/A
Completed	`NCT04752670` - ConMed Beamer Study
Completed	`NCT02314741` - Peroral Endoscopic Myotomy (POEM) for Esophageal Motility	N/A
Completed	`NCT01933373` - A Prospective Study Comparing Two Reconstructive Operation Techniques After Myotomy of Achalasia	N/A
Enrolling by invitation	`NCT03654066` - Botox or Botox With Esophageal Dilation in Patients With Achalasia	Phase 4