Botox or Botox With Esophageal Dilation in Patients With Achalasia

Status Enrolling by invitation

Clinical Trial Summary

Achalasia is a rare esophageal motility disorder. Treatment of achalasia is aimed toward palliation of symptoms. These include botox injections to the lower esophageal sphincter (LES), pneumatic dilation, surgical myotomy, and per-oral endoscopic myotomy (POEM). Botox injections are frequently used for patients that have significant comorbidities. The primary aim of this study is to assess symptomatic response of patient with achalasia to esophageal dilation and botox injection to the LES compared to standard therapy of only botox injection.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03654066
Study type	Interventional
Source	Vanderbilt University Medical Center
Contact
Status	Enrolling by invitation
Phase	Phase 4
Start date	May 13, 2019
Completion date	June 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01399476` - Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia	N/A
Recruiting	`NCT05326113` - The Effect of Physiotherapy on Post POEM Reflux	N/A
Recruiting	`NCT06044155` - redoPOEM : Failure of a First POEM
Recruiting	`NCT02989883` - Clinical Outcomes of Peroral Endoscopic Myotomy	N/A
Terminated	`NCT02606578` - Achalasia Patient Reported Outcomes
Recruiting	`NCT01793922` - POEM Trial: Multi-center Study Comparing Endoscopic Pneumodilation and Per Oral Endoscopic Myotomy (POEM)	N/A
Recruiting	`NCT01302288` - Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia	Phase 2
Terminated	`NCT03875365` - Institutional Outcome Data From Per-oral Plication of the Esophagus
Enrolling by invitation	`NCT02770859` - Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository
Recruiting	`NCT05905016` - Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
Completed	`NCT01692106` - A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia	N/A
Completed	`NCT01405469` - Endoscopic Peroral Myotomy for Treatment of Achalasia	N/A
Completed	`NCT01402518` - Per-Oral Endoscopic Myotomy
Not yet recruiting	`NCT00790465` - Efficacy of Dark Chocolate in Achalasia Patients	Phase 1/Phase 2
Recruiting	`NCT01799967` - Minimally Invasive Surgery of the Gastro-esophageal Junction
Terminated	`NCT00604942` - vMII for Measurement of Oesophageal Bolus Transport and Reflux	N/A
Recruiting	`NCT06405412` - Effects of Malnutrition on Respiratory and Renal Functions in Patients Undergoing Peroral Endoscopic Myotomy (POEM)	N/A
Not yet recruiting	`NCT06042127` - POEM-F for Achalasia International Study	N/A
Completed	`NCT04752670` - ConMed Beamer Study
Completed	`NCT02314741` - Peroral Endoscopic Myotomy (POEM) for Esophageal Motility	N/A