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Achalasia clinical trials

View clinical trials related to Achalasia.

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NCT ID: NCT03875365 Terminated - Achalasia Clinical Trials

Institutional Outcome Data From Per-oral Plication of the Esophagus

Start date: October 2, 2018
Phase:
Study type: Observational

Researchers are reviewing and analyzing surgical and clinical outcomes of subjects who underwent POPE for end-stage achalasia, a sigmoid esophagus, or a redundant conduit that has been used to replace the esophagus. This data will help researchers determine the safety and efficacy of a novel minimally invasive treatment compared to invasive surgery.

NCT ID: NCT03411252 Terminated - Achalasia Clinical Trials

Mirabegron in Achalasia: A Clinical and Manometric Proof of Concept Pilot Study

Start date: February 15, 2018
Phase: Early Phase 1
Study type: Interventional

This study evaluates whether a medication called mirabegron is better than placebo (sugar pill) in helping patients with achalasia swallow better. Each patient will receive either mirabegron or the placebo for 4 weeks followed by the opposite medication. Each patient will complete several surveys and undergo several tests to determine if the mirabegron is helping reduce the pressures in the esophagus (swallowing tube).

NCT ID: NCT02931565 Terminated - Achalasia Clinical Trials

Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia

Start date: April 6, 2017
Phase: Phase 2
Study type: Interventional

The objectives of this study are as follows: In participants with primary Type I or II achalasia, following a single 5-mg dose of olinciguat (IW-1701), - To assess the safety and tolerability - To determine the effects on measures of esophageal function by high-resolution impedance manometry (HRIM) - To determine the pharmacokinetic (PK) parameters

NCT ID: NCT02606578 Terminated - Achalasia Clinical Trials

Achalasia Patient Reported Outcomes

Start date: October 2015
Phase:
Study type: Observational

Patients that are either scheduled to undergo or have undergone an achalasia procedure at the Mayo Clinic Rochester are asked to participate. The purpose of this study is to gather information and determine if one of these procedures is superior to the other.

NCT ID: NCT02055469 Terminated - Achalasia Clinical Trials

Achalasia: Mechanisms Underlying Treatment Failure

Start date: March 2014
Phase:
Study type: Observational

In patients with achalasia, the relationship between the perception of dysphagia, oesophageal emptying, lower oesophageal sphincter (LOS) distensibility and oesophageal circular and longitudinal muscle contraction is not clear. We aim to characterize oesophageal circumferential and longitudinal muscle contractility and LOS distensibility in patients with achalasia (either before or after treatment). This may allow an understanding of the mechanisms underlying persistent dysphagia and delayed oesophageal emptying after treatment.

NCT ID: NCT01405417 Terminated - Achalasia Clinical Trials

Endoscopic Peroral Myotomy for Treatment of Achalasia

Start date: April 2011
Phase: N/A
Study type: Interventional

This study intends to investigate the feasibility, safety and efficacy of peroral endoscopic myotomy for the treatment of achalasia in a multi center setting.

NCT ID: NCT00604942 Terminated - Achalasia Clinical Trials

vMII for Measurement of Oesophageal Bolus Transport and Reflux

vMII
Start date: November 2007
Phase: N/A
Study type: Interventional

Recent work at St. Thomas' has validated an innovative new design of a multichannel intraluminal impedance (MII) catheter that is sensitive to variation in oesophageal volume in healthy volunteers and patients. This project will establish the clinical value of volume sensitive MII (vMII) compared to conventional MII acquired simultaneously by the same catheter (ROC analysis). Studies will assess: 1. The accuracy of volume measurements and correlation between symptoms and the volume of bolus retention in patients with dysphagia. 2. The accuracy of volume measurements and correlation between symptoms and reflux volume in patients with reflux disease. Follow up studies after appropriate treatment will assess whether symptomatic improvement is associated with a reduction in oesophageal volume retention/reflux. The vMII technique will be applied with high resolution manometry (HRM). These investigations are complementary in that vMII assesses the success or failure of bolus transport (or occurrence of reflux) and HRM can assess: 1. the oesophageal dysfunction that results in bolus escape 2. the abnormal events at the gastro−oesophageal junction (reflux barrier) that allow reflux to occur. with a reduction in oesophageal volume retention / reflux.

NCT ID: NCT00204763 Terminated - Fecal Incontinence Clinical Trials

Comparison of Esophageal and Anorectal Manometry Catheters

Start date: January 2004
Phase: Phase 4
Study type: Interventional

The primary objective of this study is to compare the accuracy of esophageal and anorectal manometric pressure measurements using a newly developed air filled balloon catheter with present standard solid state esophageal and anorectal catheters, respectively.