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Abortion, Habitual clinical trials

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NCT ID: NCT06007560 Recruiting - Clinical trials for Recurrent Pregnancy Loss

Aerobe Cycling Training in Women With Unexplained Recurrent Pregnancy Loss

HMOVE
Start date: March 21, 2022
Phase: N/A
Study type: Interventional

In 50% of women with recurrent pregnancy loss (RPL) miscarriages are unexplained, therefore no therapeutic intervention is possible. In a pilot study, women with unexplained RPL showed less endometrial NK cells (eNK) compared to women with a previously uncomplicated pregnancy. It is known that eNK cells are important for embryo implantation during early pregnancy. Investigators presume that high sympathetic activity in these women is related to eNK cell number, function and phenotype and that exercise is an effective intervention to lower sympathetic activity and to influence the immune system, as especially peripheral NK cells have been assumed to be responsive to physical training. The investigators hypothesize that moderate exercise can lower the adrenergic tone of the sympathetic nervous system hereby influencing endometrial NK cells in women with RPL and eventually pregnancy outcome.

NCT ID: NCT05989178 Recruiting - Clinical trials for Recurrent Pregnancy Loss

Prospective Recurrent Pregnancy Loss Registry

Start date: July 12, 2022
Phase:
Study type: Observational [Patient Registry]

The purpose of this Registry is to prospectively collect data of Recurrent Pregnancy Loss (RPL) patients attending the specialized care centre at the BC Women's Hospital, in order to evaluate investigation practices, treatment options, and outcomes for this patient population over time.

NCT ID: NCT05969574 Recruiting - Infertility, Female Clinical Trials

Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?

Start date: September 9, 2023
Phase:
Study type: Observational

This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.

NCT ID: NCT05824897 Recruiting - Pregnancy Related Clinical Trials

The Cohort Study of the Correlation Between Serum 25(OH)D Level and Pregnancy Outcome

Start date: November 1, 2022
Phase:
Study type: Observational

The objective of this single-center prospective observational study is to clarify the trend of maternal serum 25(OH)D levels before pregnancy and during pregnancy, and to explore the correlation between serum 25(OH)D levels and subsequent pregnancy outcomes of patients with abortion, so as to provide certain scientific evidence for finding the optimal serum level of 25(OH)D and optimal vitamin D supplementation to maintain a healthy pregnancy.

NCT ID: NCT05725512 Recruiting - Fertility Disorders Clinical Trials

Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages

PREMI
Start date: January 29, 2024
Phase: Phase 2
Study type: Interventional

Recurrent miscarriages (RM) affects 3% of all fertile couples, but remains unexplained in most cases, limiting therapeutic options. Possibly the maternal immune system plays a role in recurrent miscarriage. Prednisolone suppresses the immune system and might enable development of normal pregnancy. In this randomized controlled clinical trial the investigators will study the effect of prednisolone on the live birth rate in patients with RM. Secondary, the tolerability and safety for mother and child and the cost-effectiveness is investigated. In the study one group of pregnant women with RM and gestational age <7 weeks will receive prednisolone, the other group will receive a placebo. Total use of the medicine during this study is 8 weeks, further care during the study is routinely antenatal care. Subjects will be asked to fill in 4 short questionnaires and will have contact with a research nurse at different time points to gain information on the course of the pregnancy and possible side effects. Results of the study will be implemented in (inter) national guidelines, to effect everyday practice.

NCT ID: NCT05656846 Recruiting - Clinical trials for Recurrent Pregnancy Loss

Biweekly Follow-Up and At-Home Ultrasound Reduce Anxiety in Women With Recurrent Pregnancy Loss

Start date: July 15, 2022
Phase: N/A
Study type: Interventional

Spontaneous pregnancy loss is a relatively common phenomenon, with 10-15% of clinically recognized pregnancies ending in miscarriage.1 Recurrent pregnancy loss (RPL) is a disorder defined by two or more failed pregnancies2. According to various studies, pregnancy loss has been described as a traumatic event for couples even if the loss occurs at a very early stage of pregnancy. Few controlled studies dealt with the effects of the miscarriage on the psychological condition of women during a subsequent pregnancy, 4,6-8. This study aimed to evaluate the effectiveness of "at home ultrasound" in addition to routine prenatal care in reducing maternal anxiety during pregnancy for patients with history of recurrent pregnancy loss. i. Inclusion criteria: 1. Patients with recurrent pregnancy losses in first trimester 2. Current pregnancy gestational age 12-14 week of gestation 3. Singleton pregnancy ii. Exclusion criteria: 1. Female subjects who refuse to participate 2. Female subjects who don't speak Hebrew Device details: Pulsenmore Specifications: Compatible with: Android mobile phones with USB type C connector (Samsung S8+, Nokia 8, Nokia 7.1) ApplicatThe aim of this study is to evaluate the effectiveness of "at home ultrasound" in addition to routine prenatal care in reducing maternal anxiety during pregnancy for patients with history of recurrent pregnancy loss.ion: PulseNmore ES™, downloadable from Google Play™ Store.

NCT ID: NCT05648136 Recruiting - Clinical trials for Recurrent Miscarriage

Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage

ERIM
Start date: December 2, 2022
Phase: N/A
Study type: Interventional

Implantation is a determining step in human reproduction which requires the transition from a pro-inflammatory state to an anti-inflammatory state allowing the implantation of a competent embryo within a receptive endometrium, and then the maternal immunotolerance towards the alloantigenic fetus. Repeat implantation failures (RIFs), that refers to the fail to achieve a clinical pregnancy after the transfer of at least 3-4 good quality embryos or two blastocysts, and unexplained recurrent spontaneous miscarriage (RM) (≥2-3) could be related in some patients to immune imbalances characterized by an excessive and prolonged inflammatory response and/or a defect of anti-inflammatory regulation. In this context, several therapies have been evaluated in patients with RIFs or RMs in order to restore the immune balance, with heterogeneous results. No serum biomarker assay has been routinely approved to identify patients with immune imbalances that may explain repeated pregnancy failures and to predict the success of the subsequent IVF/ICSI cycle. The immunological analysis on peripheral blood will be based on the determination of the proportions of immune subpopulations (e.g. CD4+ et CD8+, TH1, TH2, TH17, Treg, ILC 1, ILC2, and ILC3) on the one hand and the circulating level of plasma cytokines on the other hand.

NCT ID: NCT05444283 Recruiting - Clinical trials for Recurrent Pregnancy Loss

Genomic Predictors of Recurrent Pregnancy Loss

GPRPL
Start date: September 1, 2021
Phase:
Study type: Observational

The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.

NCT ID: NCT05340556 Recruiting - Clinical trials for Recurrent Pregnancy Loss, Not Pregnant

Microchimerism in Patients With Recurrent Pregnancy Losses

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

This pilot study aims to evaluate if microchimeric cells in a patient with recurrent pregnancy loss (RPL) can be detected by the blood analysis for the presence of the DYS14 gene and the use of indel-panel methods and also, to examine if this method can distinguish the cell's origin; comparing gene sequence from the patient's firstborn son or her older brother. In addition, the pilot study will provide the investigators with information and experience necessary for a subsequent main study to be conducted.

NCT ID: NCT05267678 Recruiting - Clinical trials for Recurrent Miscarriage

Nutritional Deficiency and Recurrent Miscarriage

Start date: January 28, 2023
Phase:
Study type: Observational

This prospective cohort study primarily aims to examine the association between blood niacin levels and recurrent miscarriage.