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Abdominal Hysterectomy clinical trials

View clinical trials related to Abdominal Hysterectomy.

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NCT ID: NCT04724564 Recruiting - Clinical trials for Abdominal Hysterectomy

Correlation of Different Time Measurements of the Surgical PLETH Index With Postoperative Pain

Start date: February 1, 2021
Study type: Observational

Despite the major progress in anesthetic techniques, postoperative pain is still considered a major problem during practice. (1-3). Leading to many co-morbidities, one to two-thirds of patients will suffer postoperative pain. These co-morbidities can include; pulmonary complications, cardiac complications, and delirium(4). Numerous risk factors are associated with the emergence of postoperative pain, including; younger age, female sex, preoperative pain, and extensive surgical procedure. The severity of postoperative pain may vary among patients undergoing the same operation (5-10). Many techniques have been evolved to monitor nociception and predict postoperative pain intensity; one of the most recent techniques is the surgical pleth index (SPI)(11).SPI is a noninvasive dimensionless score; its value is obtained from heartbeat interval and pulse wave amplitude monitored by pulse oximetry probe.SPI reflects the sympathetic response of the patient to the surgical stimuli(12-13). It was reported that SPI is better than other parameters like heart rate and blood pressure for detecting the balance between nociceptor activation and analgesia(14-15), and its value is correlated with the severity of postoperative pain. SPI values range from 0 to 100, and higher values indicate strong surgical stimulus (16). SPI can be used as a guide for intraoperative analgesia; hence, it can be a valuable tool to assess the analgesic requirement and limit opioid consumption, both preoperative and postoperative(17). Several studies have been performed to predict the severity of postoperative pain using SPI in adults and children (16,18). It was also used successfully to expect a hemodynamic response to tracheal intubation and skin incision (19) and monitor nerve block success. (20). However, since SPI has emerged, the most sensitive cut-off value that correlates well with postoperative pain severity remained debatable. Recent studies reported a value of 30 as a cut-off value of SPI. (21). On the other hand, the time of measurement to rely on was debatable. Most studies recommended that a measure of SPI before recovery can be used. However, a more recent study suggested that SPI response to surgical incision is highly correlated with postoperative pain and opioid consumption (18). Based on these data, we hypothesized that both measurements are correlated with postoperative pain and aimed to test which measure is more correlated.

NCT ID: NCT04366375 Completed - Clinical trials for Laparoscopic Hysterectomy

Pentraxin-3 in Hysterectomy Patients

Start date: January 13, 2015
Study type: Observational

Comparison of the Tissue Trauma Markers Following Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy

NCT ID: NCT03965637 Completed - Clinical trials for Abdominal Hysterectomy

Intravenous Ascorbic Acid Administration in Hysterectomy

Start date: August 23, 2019
Phase: Phase 3
Study type: Interventional

vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.

NCT ID: NCT03748108 Completed - Clinical trials for Abdominal Hysterectomy

Bolus Administration of Intravenous Lidocaine at the Time of Abdominal Hysterectomy

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The objective of the study to evaluate whether a bolus administration of intravenous lidocaine decreases postoperative pain and represents an opioid-minimizing strategy after abdominal hysterectomy compared with placebo.

NCT ID: NCT03443271 Completed - Postoperative Pain Clinical Trials

Effect of TAP Block on Stress Hormones

Start date: June 17, 2016
Phase: Phase 4
Study type: Interventional

Random allocation of patients in two groups; Tap block group (T group) and control group (C group). All patients will receive standard general anesthesia and postoperative pain management. The TAP group patient will receive ultrasound guided (US) TAP block with 20 cc of 0.25% of bupivacaine and control group will receive 20cc of normal saline. TAP block in both groups will be performed with US guidance and the study drug will be injected after complete visualization of the needle tip between the internal oblique and the transversus abdominis muscles. Venous blood samples (5 ml for each time) for metabolic and stress hormones, including, Serum cortisol and nor-epinephrine will be collected before anesthesia at the time of cannulation (T1),60 minutes after incision(T2), 6hrs (T3)and 12 h (T4) after the surgery. Postoperatively patient will be put on patient controlled intravenous infusion of nalbuphine

NCT ID: NCT01492075 Completed - Clinical trials for Abdominal Hysterectomy

A Comparison Between Continuous and Intermittent Intraabdominal Analgesia Using Local Anaesthetics

Start date: January 2008
Phase: Phase 4
Study type: Interventional

The investigators hypothesis is that patient controlled local anesthetics administered intraabdominally are more efficacious compared to continuous infusion in reducing postoperative pain and morphine consumption.