Clinical Trials Logo
  1. Home
  2. Vascular Disease
  3. NCT02931188

The Effect of Anacetrapib on Vascular Function and Arterial Stiffness — REVEAL-Vasc  

Vascular Disease Clinical Trial

Official title:
A Cross-sectional REVEAL Sub-study Evaluating the Effect of Anacetrapib on Vascular Function and Arterial Stiffness [An Investigator Led Sub-study of HPS3/TIMI 55: REVEAL]

Clinical Trial Summary

There are currently no studies evaluating the effect of anacetrapib on blood vessel function and stiffness of the arteries. The REVEAL-Vasc trial will assess whether anacetrapib, in addition to atorvastatin (LDL-C lowering drug) treatment, results in greater endothelial-dependent vascular function and aortic stiffness in patients with established cardiovascular disease, compared to adding placebo. Participants will be asked to provide a blood sample and pulse Wave Velocity/Pulse Wave Analysis and Flow Mediated Dilation will be carried out to assess blood vessel function and stiffness of the arteries. REVEAL-Vasc is an investigator led sub-study of HPS3/TIMI 55: REVEAL (Randomized Evaluation of the Effects of Anacetrapib through Lipid modification): A large-scale, randomized placebo-controlled trial of the clinical effects of anacetrapib among people with established vascular disease (NCT01252953) which is coordinated by OXFORD CTSU. No treatment will be received on this sub-study, therefore only participants who have been enrolled in HPS3/TIMI55 REVEAL in which participants received anacetrapib with atorvastatin or placebo will be considered for this trial.

Clinical Trial Description

REVEAL-Vasc is an investigator led sub-study of HPS3/TIMI 55: REVEAL. Participants who previously enrolled on HPS3/TIMI 55: REVEAL and received treatment will be invited to participate in this sub-study. Participants will attend a screening and an assessment visit during which Pulse Wave Velocity/ Pulse Wave Analysis and Flow Mediated Dilation will be carried out to assess blood vessel function and stiffness. A blood sample will also be taken from participant to assess CRP and lipid profile. Since participants will have received treatment on the main trial HPS3/TIMI 55: REVEAL, no treatment will be received on this sub-study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02931188
Study type Observational
Source Cambridge University Hospitals NHS Foundation Trust
Contact
Status Completed
Phase
Start date January 2017
Completion date May 2018
View Details
See also
  Status Clinical Trial Phase
Completed NCT01205776 - EXCEL Clinical Trial N/A
Completed NCT02542267 - In-Stent Restenosis Post-Approval Study N/A
Completed NCT01608035 - Sciatic Perineural Versus Stump Catheter for Below Knee Amputation Phase 0
Completed NCT00987181 - Non-Contact Measurement of Aortic Compliance N/A
Completed NCT00865124 - Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease N/A
Completed NCT00759681 - ArterX Surgical Sealant, A Randomized Prospective Multicenter Trial Phase 3
Completed NCT01182428 - XIENCE V: SPIRIT WOMEN Sub-study Phase 4
Completed NCT00633659 - Pilot Study of Hemospan® in Patients With Chronic Critical Limb Ischemia Phase 2
Completed NCT00341562 - Genomics of In-Stent Restenosis N/A
Completed NCT00110604 - The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing N/A
Completed NCT01355406 - Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System N/A
Not yet recruiting NCT02843854 - Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms Phase 1
Completed NCT01205789 - EXCEL Clinical Trial (Universal Registry) N/A
Completed NCT01221610 - BIOLUX P-I First in Man Study N/A
Completed NCT01229358 - Clinical Trial of a Silver Eluting Dressing System Phase 4
Recruiting NCT01358630 - Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities N/A
Completed NCT00782015 - Effects of Almonds on Vascular Reactivity in Patients With Coronary Artery Disease N/A
Completed NCT00805831 - Safety and Efficacy of Using HDH Device and Method - a Novel Sutureless Vascular Anastomosis N/A
Withdrawn NCT00334724 - Home Blood Pressure-guided Antihypertensive Intervention for Elderly (HBP-GUIDE) Study Phase 4
Active, not recruiting NCT02751099 - Bone and Cardiovascular Disease After Kidney Transplant