Clinical Trials Logo

Valvular Heart Disease clinical trials

View clinical trials related to Valvular Heart Disease.

Filter by:

NCT ID: NCT02136979 Completed - Clinical trials for Valvular Heart Disease

Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery

Start date: May 21, 2014
Phase: Phase 4
Study type: Interventional

CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression. Propofol and volatile anesthetics were related to immune reaction. However, the effect of propofol and sevoflurane on the change of CD39 and CD73 after CPB was not evaluated in previous studies. The authors hypothesized that the expression of CD39 and CD73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing CPB. Therefore, the present study determined the effect of propofol and sevoflurane on CD39 and CD73 during and after CPB.

NCT ID: NCT01826149 Completed - Clinical trials for Coronary Artery Disease

Propofol Effects on Mitral Valve Annular Velocity

Start date: April 2013
Phase: Phase 4
Study type: Interventional

The purpose of this study is primarily to determine the effects of propofol at different concentration on the mitral valve annulus by using Tissue Doppler Imaging

NCT ID: NCT01825720 Completed - Clinical trials for Valvular Heart Disease

Effect of Glucose-Insulin-Potassium on Hyperlactatemia in Patients Undergoing Valvular Heart Surgery

Start date: March 2013
Phase: N/A
Study type: Interventional

Hyperlactatemia, occuring 10-20% in patients undergoing valvular heart surgery, is known to be associated with hemodynamic instability, organ dysfunction and increased postoperative morbidity and mortality. Glucose-Insulin-Potassium(GIK) has been constantly used as an adjuvant therapy in patients with myocardial infarction or in the patients undergoing valvular heart surgery to reduce the low cardiac output syndrome and mortality. GIK is known to prevent excretion of lactate and to increase the extraction of lactate after reperfusion with various mechanism. In addition, it is also known to decrease ischemic-reperfusion injury of myocardium after CPB, to improve myocardial contractility, insulin resistance and hyperglucemia. As a result, it brings hemodynamic stability and sufficient oxygen supply to the tissue, which might reduce the incidence of hyperlactatemia after valvular heart surgery.

NCT ID: NCT01819012 Completed - Clinical trials for Ischemic Heart Disease

Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery

Start date: March 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to determine Isoflurane's dose-dependent effect on left ventricular (LV) systolic function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular systolic velocity at three different isoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE) in cardiac surgery patients.

NCT ID: NCT01681095 Completed - Clinical trials for Coronary Artery Disease

Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent

Start date: August 2012
Phase: Phase 2
Study type: Interventional

The purpose of the study is to demonstrate that Custodiol-HTK is not inferior to cold cardioplegic solution in patients undergoing cardiovascular surgery requiring cardioplegic arrest.

NCT ID: NCT01676727 Completed - Aortic Stenosis Clinical Trials

ADVANCE Direct Aortic Study

Start date: September 2012
Phase:
Study type: Observational

This study is intended to collect data regarding the clinical utility, safety and performance of the Medtronic CoreValve® System for Transcatheter Aortic Valve Implantation (TAVI) in patients with severe symptomatic aortic valve stenosis for which treatment via direct aortic access (DA) is selected.

NCT ID: NCT01624870 Completed - Clinical trials for Aortic Valve Stenosis

CoreValve Advance-II Study: Prospective International Post-market Study

Advance-II
Start date: October 2011
Phase:
Study type: Observational

The CoreValve ADVANCE-II Study is a best practices investigation of patients implanted with the Medtronic CoreValve bioprosthesis.

NCT ID: NCT01623193 Completed - Clinical trials for Coronary Artery Disease

The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot Study

ABC
Start date: April 23, 2012
Phase: N/A
Study type: Interventional

This study is a single centre pilot for a randomized trial comparing all-blood cardioplegia to more dilute 4:1 blood cardioplegia during cardiac surgery. The hypothesis is that all-blood cardioplegia will be associated with less blood transfusion and better cardiac function.

NCT ID: NCT01511991 Completed - Clinical trials for Valvular Heart Disease

Sevoflurane's Effect on Mitral Valve Annular Velocity in Cardiac Surgery

Start date: May 2009
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to determine sevoflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular velocity at three different sevoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE)in cardiac surgery patients.

NCT ID: NCT01495949 Completed - Clinical trials for Coronary Artery Disease

The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone

Start date: December 2011
Phase: Phase 4
Study type: Interventional

During induction for cardiac surgery, patient hemodynamic stability is achieved by using anesthetic drugs which least affects hemodynamics such as benzodiazepines, etomidate. Etomidate although has been used for a long time but its safety regarding cortisol synthesis suppression is still doubtful. This study measures the changes in cortisol levels during cardiac surgery with the use of cardiopulmonary bypass by comparison between two inductive agents (etomidate and thiopentone). Recording data also include hemodynamic changes during induction, inotropic use for coming of cardiopulmonary bypass, blood glucose levels, amount of insulin usage, length of ICU and hospital saty.