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Ulcer clinical trials

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NCT ID: NCT05791929 Withdrawn - Clinical trials for Diabetes Mellitus, Type 2

LSCI and Thermography in Diabetic Foot Patients Affected by Ulcer(s): (MY-FOOT-B)

MY-FOOT-B
Start date: April 13, 2023
Phase:
Study type: Observational

The objective of this observational study is to predict healing at 26 weeks after the first visit in patients affected by the first ulcer, by means of combined data monitoring of Laser Speckle Contrast Imaging (LSCI) and temperature measurements during patient visits in hospital. In order to achieve this objective, study aims to produce a logistic regression model and then evaluate its prognostic ability by means of the area under the curve (AUC) of the receiver-operating-characteristics (ROC) curve. Patients with diabetes mellitus and suffering from ulcer and receiving health care will undergo regular microcirculatory measurements including LSCI scans in and around the ulcer location and thermography.

NCT ID: NCT05578508 Withdrawn - Crohn's Disease Clinical Trials

Stem Cells for the Treatment of Pouchitis

Start date: April 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety and feasibility of using allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat people with medically refractory Pouchitis.

NCT ID: NCT05172349 Withdrawn - Corneal Ulcer Clinical Trials

Use of a Biological Lens of Amniotic Membrane (LV-Visio-AMTRIX) in the Treatment of Trophic Ulcers

Start date: April 2022
Phase: Phase 2
Study type: Interventional

The purpose of this open, multicenter pilot trial is to assess the impact of the use of an amniotic membrane on the healing of a persistent epithelial lesion or of a corneal ulcer.

NCT ID: NCT05121402 Withdrawn - Ulcerative Colitis Clinical Trials

Safety and Efficacy Study of TLL018 in the Treatment of Ulcerative Colitis

Start date: December 30, 2022
Phase: Phase 2
Study type: Interventional

A study to investigate the safety and efficacy of TLL018 compared with placebo in subjects with moderate to severe ulcerative colitis.

NCT ID: NCT05024656 Withdrawn - Diabetic Foot Ulcer Clinical Trials

AmnioExcel® Plus vs SOC in the Management of Diabetic Foot Ulcers

Start date: September 2021
Phase: N/A
Study type: Interventional

This is a prospective, multicenter, randomized, parallel-group Trial comparing the outcomes associated with the use of AmnioExcel® Plus Placental Allograft Membrane (AmnioExcel® Plus) used in conjunction with Standard of Care (SOC) compared to SOC alone in the management of diabetic foot ulcers (DFUs).

NCT ID: NCT04898348 Withdrawn - Ulcerative Colitis Clinical Trials

A Study to Investigate Efficacy and Safety of KBL697 in Patients With Mild to Moderate Active Ulcerative Colitis

Start date: January 14, 2022
Phase: Phase 2
Study type: Interventional

The study is designed to investigate efficacy and safety of KBL697 in patients with mild to moderate active ulcerative colitis. KBL697 has been developed as a potential new treatment for ulcerative colitis.

NCT ID: NCT04802928 Withdrawn - Arterial Leg Ulcer Clinical Trials

Healing of Ischemic Leg Ulcers in Patients Treated With iSONIAzid

SONIA
Start date: April 2008
Phase: Phase 2
Study type: Interventional

The main objective of this trial is to study the healing effect of an oral drug (isoniazid) in patients with ischemic (arterial) leg ulcers defined by a systolic toe pressure <40 mm Hg.

NCT ID: NCT04469062 Withdrawn - Ulcerative Colitis Clinical Trials

A Study of Mirikizumab (LY3074828) in Participants With Ulcerative Colitis

LUCENT-ACT
Start date: April 20, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate if study drug mirikizumab is safe and effective compared to vedolizumab and placebo in participants with moderately to severely active ulcerative colitis (UC).

NCT ID: NCT04348890 Withdrawn - Clinical trials for Pediatric Ulcerative Colitis

Proof of Concept Trial of Vamorolone in Pediatric Ulcerative Colitis

Start date: September 1, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Phase I/II, multi-center, open-label proof-of-concept study of vamorolone. Twenty participants with a flare of mild or moderately active Ulcerative Colitis (defined as a Pediatric Ulcerative Colitis Activity Index [PUCAI] 10-60) will be enrolled and receive vamorolone 6 mg/kg/day orally once daily for 8 weeks.

NCT ID: NCT04285710 Withdrawn - Diabetes Clinical Trials

Adjunctive Phototherapy Treatment of Infected Diabetic Ulcers

Start date: June 2021
Phase: N/A
Study type: Interventional

The key purpose of this study is to determine and understand the safety and effectiveness of blue light phototherapy in the treatment and healing of infected diabetic wounds, as well as determining if this treatment is capable of reducing the bacterial population number within infected wounds. The investigators' lab recently discovered that a specific survival protein called catalase can be destroyed through blue light exposure. Given that a majority of bacteria species contains catalase, it is hypothesized that the destruction of this protein can improve the effectiveness of antimicrobial wound dressings commonly used to treat infected diabetic wounds, therefore further reducing the amount of bacteria within the wound and increasing the rate of healing. By reducing the overall bacterial population within these diabetic infected wounds, the ability for these diabetic wounds to heal will be enhanced, allowing for greater reductions in wound size over the course of the treatment. In this study, 40 subjects will be enrolled and randomly assigning subjects to either a control group or a phototherapy receiving experimental group. While control subjects will receive standard weekly debridement treatment procedures for infected diabetic ulcers, experimental subjects will receive standard weekly debridement treatment alongside 2 sessions of phototherapy every week over the course of 12 weeks. Bacterial swab samples will be taken alongside the excised debrided infect tissue for the purpose of bacterial population analysis. For each patient, the changes in total bacterial population, wound size, and subject satisfaction will be recorded and analyzed to determine the effectiveness of pulsed light phototherapy.