Type 2 Diabetes Clinical Trial
"The goal of this work is to critically test the hypothesis that there exists a different
profile of bile acids (BAs) in patient with type 2 diabetes mellitus (T2DM) compared with
normal controls. Through confirmation of different profile of BAs in T2DM, investigator will
suggest modulation of specific bile acids as a new possible treatment target in patients with
T2DM. Investigator also expect the specific BAs signature will be used to screen T2DM before
hyperglycemia.
In addition, investigator will evaluate the association between each BA species and serum
total glucagon like peptide-1 (GLP-1) or fibroblast growth factor-19 (FGF-19) concentrations
to determine if the specific BAs profile is related with total GLP-1 or FGF-19 concentration
in serum. Investigatr also evaluates the correlation between each BA species and metabolic
profiles and oxidative stress marker to find possible roles of each BA component in glucose
metabolism.
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