Type 2 Diabetes Mellitus Clinical Trial
Official title:
Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease
Aldosterone is a significant mediator of cardiovascular injury associated with heart failure
and the cardiovascular benefits of mineralocorticoid receptor blockade are additive to those
of angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. This study
will test the hypothesis that MR antagonists exert beneficial cardiovascular effects,
specifically by decreasing vascular injury and improving vascular function.A randomized,
double-blind study will be conducted, in which subjects with Type 2 Diabetes Mellitus will
undergo a series of assessments to test heart, blood vessel, and kidney function at
baseline, and after 2 and 6 months of treatment with one of the following drugs:
1. spironolactone
2. hydrochlorothiazide plus potassium
3. placebo.
In the event of insufficient funds, randomization to the placebo arm will be stopped and
primary assessment of outcomes will occur at baseline and after 6 months of treatment.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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