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Syndrome clinical trials

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NCT ID: NCT03075761 Completed - Clinical trials for Deep Vein Thrombosis

Physical Activity in Children at Risk of Post-thrombotic Sequelae (PACT)

PACT
Start date: November 18, 2016
Phase: N/A
Study type: Interventional

'The PACT trial' is randomized pilot trial to demonstrate the feasibility and potential effectiveness of a personal "fitness tracker" to improve adherence to an activity regimen following an initial acute DVT in children.

NCT ID: NCT03074227 Recruiting - Clinical trials for Irritable Bowel Syndrome

The FAIS-Trial: Faecal Microbiota Transplantation (FMT) in Adolescents With Refractory Irritable Bowel Syndrome (IBS)

FAIS
Start date: November 23, 2017
Phase: N/A
Study type: Interventional

A Double-blind randomised placebo-controlled pilot study as well as a reversed translational part To investigate whether two faecal transplantations from either allogeneic (healthy) or autologous (own) donor, administered through a nasoduodenal tube, has beneficial effects on irritable bowel syndrome (IBS) symptoms such as abdominal pain frequency and severity. Secondary objective is to study microbiota changes in faeces samples.

NCT ID: NCT03074006 Completed - Clinical trials for Myelodysplastic Syndromes

Dose Escalation and Proof-of-Concept Studies of Vactosertib (TEW-7197) Monotherapy in Patients With MDS

Start date: January 4, 2018
Phase: Phase 1
Study type: Interventional

This is a prospective, open-label, multicenter, phase 1/2 study of TEW-7197 in patients with low and intermediate risk of myelodysplastic syndrome (MDS).

NCT ID: NCT03073772 Completed - Burnout Syndrome Clinical Trials

Rehabilitation for Improved Cognition

RECO
Start date: April 1, 2010
Phase: N/A
Study type: Interventional

Many patients with exhaustion disorders continue to have significant difficulties with attention and memory function which reduce their work ability. This randomized study investigates whether the addition of a 12-week period of specific cognitive training or physical fitness training could further enhance cognitive function in patients with exhaustion disorder participating in a multimodal rehabilitation program.

NCT ID: NCT03072849 Recruiting - Clinical trials for Bronchiolitis Obliterans Syndrome

Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation

Start date: April 2015
Phase: N/A
Study type: Observational

This study aims to determine whether or not early spirometric detection and management of obstructive lung disease with combined fluticasone/azithromycin/montelukast therapy (FAM) can attenuate declining lung function, prevent the development of bronchiolitis obliterans, and improve patient outcomes following hematopoietic stem cell transplant.

NCT ID: NCT03072498 Recruiting - Clinical trials for Myelodysplastic Syndromes(MDS)

Collection of Samples From Patients With MDS

Start date: April 6, 2017
Phase:
Study type: Observational

The purpose of this study is to collect information and bone marrow, blood, saliva, cheek cells and skin to be used in the laboratory to assist the sponsor in identifying a new way of treating MDS.

NCT ID: NCT03072290 Completed - Clinical trials for Carpal Tunnel Syndrome

Corticosteroid Injection in Carpal Tunnel Syndrome

Start date: February 18, 2017
Phase: N/A
Study type: Interventional

To compare the effectiveness of different dose of ultrasound guided steroid injection in patient with carpal tunnel syndrome, by using clinical and electrophysiological parameters in evlauation

NCT ID: NCT03072043 Completed - Clinical trials for Acute Myeloid Leukemia

Phase 1b/2 Safety and Efficacy of APR-246 w/Azacitidine for tx of TP53 Mutant Myeloid Neoplasms

Start date: May 18, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The main purpose of this study is to determine the safe and recommended dose of APR-246 in combination with azacitidine as well as to see if this combination of therapy improves overall survival.

NCT ID: NCT03070691 Withdrawn - Clinical trials for Basal Cell Carcinoma

Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Start date: n/a
Phase: Phase 2/Phase 3
Study type: Interventional

This 22 week study will assess the efficacy, safety, and tolerability of LDE225 versus vehicle when applied topically to basal cell carcinoma (BCC) in patients with NBCCS. Patients will treat multiple BCCs for up to 12 weeks. Treatment success is defined as complete clinical clearance and complete histological clearance in BCCs.

NCT ID: NCT03069976 Completed - Clinical trials for Primary Sclerosing Cholangitis

"Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children"

Start date: January 2016
Phase: N/A
Study type: Interventional

Based upon the possible implication of microbiota and abnormal microbial metabolites such as altered bile acids, in the pathogenesis of PSC, emerging data suggests that oral antibiotics, such as vancomycin and metronidazole, may have therapeutic effects in this overlap syndrome or PSC. The goal of our study is to evaluate role of antibiotics and microflora in children with AIH/PSC overlap syndrome or with PSC alone. The investigators hope to learn what effects oral antibiotics has on the bacteria present in stool, and hope to learn to characterize human intestinal microbial communities, in children suffering from overlap syndrome or PSC. The hypothesis of the investigators is that overlap syndrome and PSC develop due to altered microflora and the resulting abnormal bile acids pool. The outcome of overlap syndrome or PSC could be affected by presence or absence of RCUH. Antibiotics to correct the microflora may result in disease/cholangiopathy remission.