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Deep Vein Thrombosis clinical trials

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NCT ID: NCT03835780 Not yet recruiting - Clinical trials for Rheumatoid Arthritis

The Risk of Venous Thromboembolism in Systemic Inflammatory Disorders: a United Kingdom (UK) Matched Cohort Study

Start date: February 1, 2019
Study type: Observational

Blood clots occurring in the legs and in the lungs are relatively common; they occur in around 3 in a 1000 people per year. They can cause disability and are also potentially life threatening. When a clot occurs in the legs it is called a deep vein thrombosis or DVT. When they occur in the lungs they are called a pulmonary embolism or PE. The risk for DVT and PE is higher in people with conditions which cause inflammation. The most common of these are inflammatory bowel disease (ulcerative colitis and Crohn's disease), rheumatoid arthritis, and psoriatic arthritis (a condition comprised of psoriasis and joint inflammation). What is not known is how much higher the risk of DVT and PE is in these groups compared with people without inflammatory disease, and what causes the excess risk in these people. This study aims to assess the measure the exact increase in risk for DVT and PE in people with these inflammatory conditions and to identify which risk factors are most strongly associated with the increased risk. These data should help with an understand the causes of blood clot risk in these inflammatory conditions and in identify targets for reducing risk.

NCT ID: NCT03812848 Active, not recruiting - Atrial Fibrillation Clinical Trials

Clinical Pharmacist-led Inpatient Anticoagulation Stewardship Program

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

This study aims at evaluating the implementation of clinical-pharmacist-led anticoagulation stewardship program in Egyptian tertiary hospital to promote a culture of safety around anticoagulants.

NCT ID: NCT03784937 Recruiting - Clinical trials for Deep Vein Thrombosis

Revaluation of Wells' Clinical Prediction Score of Deep Vein Thrombosis (DVT) in Inpatients With Thromboprophylaxis Treatment

Start date: February 1, 2018
Study type: Observational

This study aimed (1) revaluating the efficacy of the Wells' clinical prediction score for an inpatient population; and the weight of the presence of thromboprophylaxis treatment on the score, and (2) evaluating the correlation of a risk stratification established between a physician specialised in thrombosis and any other doctor.

NCT ID: NCT03757481 Not yet recruiting - Clinical trials for Deep Vein Thrombosis

Long-term Outcome After Heparin and Edoxaban Versus Heparin Plus Vit K Antagonists for Acute DVT and PE

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Centers that participated in the Hokusai VTE trial will be invited to collect follow of previously enrolled patients at least 2 years after the index VTE.

NCT ID: NCT03682419 Recruiting - Atrial Fibrillation Clinical Trials

Evaluation of Precision and Accuracy of INR Measurements in a Point of Care Device (OPTIMAL)

Start date: September 17, 2018
Phase: N/A
Study type: Interventional

Comparison of capillary whole blood INR determined by LumiraDx Instrument to venous plasma INR determined by laboratory reference method (IL ACL ELITE PRO) for method comparison and assessment of accuracy and bias by regression analysis and other analytical methods.

NCT ID: NCT03650127 Enrolling by invitation - Type 2 Diabetes Clinical Trials

Returning Genome and Metabolome Data to FinTerveys 2017 Participants: FinTerveys Study

Start date: February 2, 2018
Study type: Observational study - P4 together with a fifth 'P' and '.fi' for population health Finally Implemented in Finland - studies the value of returning genetic and metabolomic risk information in two diseases (coronary heart disease and type 2 diabetes) and one feature (venous thromboembolism). The hypothesis of the study is that 1) combining genetic and metabolic risk with traditional risk factors adds value to the personal risk assessment of these diseases, 2) such risk information can be provided to individuals using a web based user portal in an easily understandable and useful format, and 3) receiving genetic and metabolomic risk information has an effect on the health of the study participants. The study is a continuation of FinHealth 2017 -study, which involved more than 7,000 Finns from around the country. The participants of FinHealth were invited to participate in -study. The new research utilises information, samples, and measurements obtained in the FinHealth Study. Prospective clinical significance of selected genetic and metabolomic risk scores will be studied in 30.000 Finnish individuals. The study will analyze the genetic and metabolomic profile of the participants and develop and test a protocol for returning them health related risk information. The impact of the intervention will by followed up by questionnaires and national health registers for five years.

NCT ID: NCT03634124 Not yet recruiting - Clinical trials for Deep Vein Thrombosis

Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs

Start date: January 2019
Phase: Phase 3
Study type: Interventional

The numerical ratio between the value of the thrombin generation test performed without soluble thrombomodulin and the value of the thrombin generation test performed in the presence of soluble thrombomodulin, performed pre-surgically, could predict the risk of early venous thromboembolism after placement of total hip or knee prosthesis.

NCT ID: NCT03590743 Recruiting - Clinical trials for Deep Vein Thrombosis

Calf Deep Vein Thrombosis Treatment Trial

Start date: December 29, 2018
Phase: Phase 4
Study type: Interventional

The primary objective is to evaluate whether apixaban is more effective in treating patients with isolated calf vein thrombosis (DVT) than serial imaging of the DVT for preventing thrombus spread, pulmonary embolism (PE) and/or recurring DVTs.

NCT ID: NCT03573492 Recruiting - Pulmonary Embolism Clinical Trials

Bedside Ultrasound in the Assessment of Deep Venous Thrombosis: Effectiveness of In-Person Versus Online Instruction

Start date: June 4, 2018
Phase: N/A
Study type: Interventional

This study will examine the effectiveness of pre-recorded instructional videos in the use of bedside ultrasonography to ascertain the presence of a lower extremity deep venous thrombosis (DVT) as compared to in-person lectures and hands-on training.

NCT ID: NCT03516656 Recruiting - Clinical trials for Venous Thromboembolism

Evaluation of Anti-Xa Levels in Surgery Patients Receiving Weight-based Heparin

Start date: March 23, 2018
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to determine if weight-based heparin infusions at a rate of 10 units/kg/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for VTE prophylaxis in patients undergoing microvascular surgery. Additionally, a pilot protocol has been developed to titrate these heparin infusions to ensure patients have sufficient VTE prophylaxis. All patients will be enrolled in the observational arm of the study and receive anti-Xa level monitoring. Patients with out-of-range anti-Xa levels will cross over to the interventional arm of the study and receive real time heparin infusion dose adjustments per the pilot protocol. The primary outcome measured will be the percentage of patients with anti-Xa levels in the target range of 0.1-0.35 IU/mL while on a heparin infusion at 10 units/kg/hour.