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AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke — ARCADIA  

Stroke Clinical Trial

Official title:
AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

Clinical Trial Summary

Objectives - Primary: To test the hypothesis that apixaban is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy. - Secondary: To test the hypothesis that the relative efficacy of apixaban over aspirin increases with the severity of atrial cardiopathy.

Clinical Trial Description

ARCADIA is a multicenter, biomarker-driven, randomized, double-blind, active-control, phase 3 clinical trial of apixaban versus aspirin in patients who have evidence of atrial cardiopathy and a recent stroke of unknown cause. Eleven hundred subjects will be recruited over 2.5 years at up to 200 sites in and out of the NINDS StrokeNet consortium. Subjects will be followed for a minimum of 1.5 years and a maximum of 7 years for the primary efficacy outcome of recurrent stroke and the primary safety outcomes of symptomatic intracranial hemorrhage and major hemorrhage other than intracranial hemorrhage. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03192215
Study type Interventional
Source Columbia University
Contact
Status Terminated
Phase Phase 3
Start date January 19, 2018
Completion date April 17, 2023
View Details
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