Stroke Clinical Trial
Official title:
Assessment of Social-emotional Functioning in Stroke, Frontotemporal Dementia, Alzheimer and Parkinson Diseases
Empathy, defined as the ability to understand others emotions, is a fundamental concept in
social interactions. It is a psychological phenomenon involving various separable components
: (i) the ability to feel and imagine the emotions, (ii) the ability to adopt the
perspective of other people. Several neurological diseases with behavioral disorders may
lead to impaired processing of social and/or emotional informations. These pathologies are
likely to induce a lack of empathy that may result from impairments at different levels.
The objective is simply to study how others' emotions are understood and how this allows for
regulation of personal behavior. This study is being carried out among patients seen for
various health problems and who can make behavior changes. This study could help to
understand some neurological diseases and thereby to identify them earlier and/or to better
differentiate them.
Empathy is a fundamental concept in social interactions, whose function is to understand the
emotions felt by others. According to De Waal (2008), it is a multidimensional concept that
involves two processes :(i) a system of emotional contagion or affective resonance (the
unconscious and automatic sharing of the emotion of others) that establishes the emotional
component of empathy, (ii) the ability to take perspective, that is the ability to imagine
the subjective world of the other distinguishing oneself from him, forming the cognitive
component of empathy.
Several neurological diseases with behavioral disorders may lead to impaired processing of
social and/or emotional information. These pathologies are likely to induce a lack of
empathy that may result from impairments at different levels.
The main objective of this study is to examine empathy in patients suffering from stroke
(various locations with an emphasis on frontal stroke), Fronto-temporal dementia, Alzheimer
and Parkinson diseases. The final assessment criterion is the overall score on the scale of
empathy.
The patient will firstly receive a medical examination and clinical data are collected (past
medical history, clinical neurological examination, diagnosis, description of first
symptoms, course, current treatments)and brain imaging data. After checking inclusion
criteria, information letter and the consent form will be returned.
The second visit will consist in neuropsychological assessment: general intellectual
efficiency, perceptual and visual-constructive abilities, memory, executive and an
assessment of behavior and mood from questionnaires The third and final visit will allow
passing experimental tests. The experimental part will include the following tests: (1)
recognition of emotional facial expressions; (2) tasks of theory of mind ; (3) task of
empathy for pain.
A control group will also perform the neuropsychological and experimental tests.
The duration of the study participation for eligible patients and controls will vary
according to the delay between each visit (medical, neuropsychological and experimental) and
is lower than 3 months. The study will take place from June 2009 to June 2013.
- Number of patients: 320
- Number of controls: 400
- Potential Benefits expected: criteria for early diagnosis and / or differential
diagnosis based on the evaluation process of empathy; elaboration of new clinical tools
assisting diagnosis.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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