The Association of Omentin and Ischemic Stroke

Stroke Clinical Trial

Official title:

The Association of Omentin and Ischemic Stroke

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03125759
• Other study ID #: NDIS001
• Status: Recruiting
• Phase: N/A
• First received: April 1, 2017
• Last updated: April 21, 2017
• Start date: January 1, 2017
• Est. completion date: December 31, 2025

Study information

• Verified date: April 2017
• Source: Xi'an No.3 Hospital
• Contact: Tian Ye, PhD
• Phone: +86 13519131549
• Email: chhty[@]sina.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This observational study aims to research whether there is a relationship between omentin and ischemic stroke on the aspects of incidence, severity, and recovery etc.

Description:

To study the possible relationship between omentin and ischemic stroke, we intend to recruit the newly found acute ischemic stroke patients and patients without any stroke history and analysis the difference of plasma omentin level and the ITLN, which is the gene symbol of omentin.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 2000
• Est. completion date: December 31, 2025
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• For ischemic stroke group,acute clinically defined ischemic stroke

• For control group, without any history of stroke

Exclusion Criteria:

For ischemic stroke group

• Hemorrhagic Stroke

• Previous Ischemic Stroke For control group

• The expected life expense less than 3 years

Related Conditions & MeSH terms

• Adipokines
• Brain Ischemia
• Ischemia
• Mutation
• Stroke

Locations

Country	Name	City	State
China	Xi'an No.3 Hospital	Xi'an	Shanxi

Sponsors (1)

Lead Sponsor	Collaborator
Xi'an No.3 Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the odds ratio of omentin plasma concentration between cases and controls	The circulation level of omentin will be assessed in cases and controls. Then the odds ratio will be statically analysed to detect whether omentin is asociated with ischemic stroke on protein level.	up to 3 years
Primary	the frequency difference of single nucleotide polymorphism(SNP) of omentin in the enrolled subjects	The SNP will be analysed in the recruited subjects. And the the frequency difference will be calculated to explore if any SNP is related to ischemic stroke.	up to 3 years
Secondary	the NIHSS assessed for functional outcome of stroke	NIHSS wil be used to assess neurological status at baseline or the point of stroke, the point of out-patient, 3 month, 6 month, 1 year, 2 year and the 3 year.	up to 3 years
Secondary	the modified Rankin Scale assessed for functional disability	Th functional disability will be assessed using the modified Rankin Scale at the time of baseline, out-patient, 3rd month, 6th month, 1st year, 2nd year and the 3rd year after enrollment.	up to 3 years
Secondary	the Barthel index assessed for functional independence in activities	The Barthel index at the point of baseline, out-patient, 3rd month, 6th month, 1st year, 2nd year and the 3rd year after enrollment will be assessed for the functional independence in activities.	up to 3 years
Secondary	the number of all cause death	The number of all cause of death will be recorded in both groups.	up to 3 years
Secondary	the number of re-stroke in case group	Recurrent of stroke will be monitored through out in case group.	up to 3 years