Stroke Clinical Trial
— HOLISTEROfficial title:
Micro-embolic Signals Detection With Transcranial HOLter in Acute Ischemic STroke: Yield in the Etiologic woR-kup
Verified date | February 2019 |
Source | University Hospital, Bordeaux |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In acute ischemic stroke, the identification of an etiology is of major importance to prevent recurrence by providing the best treatment. Because of numerous possible underlying etiologies, the etiological work-up of ischemic stroke includes a wide range of diagnostic tests, which can be invasive, long and expensive. Moreover, many patients receive a diagnosis of undetermined stroke even after all available diagnosis tests are done, precluding optimal treatment.
Status | Completed |
Enrollment | 244 |
Est. completion date | August 14, 2018 |
Est. primary completion date | May 11, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Ischemic stroke in the middle cerebral artery territory - Acute ischemic stroke within the 7 first days from the onset of the symptoms - Patient hospitalized in our stroke care unit - Man or woman older than 18 years - Patient affiliated to a social security system - Free Consent, informed writing signed by the participant or the person of confidence and the investigator (no later than the day of inclusion and before any examination required by research) Exclusion Criteria: - Transient ischemic stroke - Ischemic stroke in the vertebro-basilar or anterior cerebral artery territory. - Proximal middle cerebral artery occlusion leading to the impossibility of recording - Patient who could not express his consent - Patient under guardianship or judicial protection - Pregnant or breastfeeding woman - Emergency situation - Life expectancy under 6 months Exclusion criteria (after inclusion) : - Absent of bilateral Acoustic window - Analyzable Recording <30min |
Country | Name | City | State |
---|---|---|---|
France | CHU de Bordeaux | Bordeaux |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Bordeaux |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pattern of Microembolic signals (MES) recorded by Transcranial-holter monitoring and interpreted by an observer (index test) | Microembolic signals (MES) will be recorded using Transcranial-holter monitoring (index test) for 4 hours at the acute phase of ischemic stroke. The pattern will be described (frequency, laterality) by the observer interpreting recordings, blinded to stroke etiology as established by the reference standard. | Day 0 (inclusion) | |
Primary | Etiology of ischemic stroke according to ASCOD phenotyping (A: atherosclerosis; S: small-vessel disease; C: cardiac pathology; O: other causes D: dissection) (reference standard) | Etiologic work-up of ischemic stroke will result in ASCOD classification (reference standard) of etiology. Work-up and classification will be established blind to the pattern of microembolic signals recordede by Transcranial-holter monitoring (index test) | Month 12 | |
Secondary | Stroke recurrence | Existence of a stroke recurrence will be assessed by clinical examination and possibly additional tests (imaging,..) | Month 12 | |
Secondary | Actual duration of Transcranial-holter monitoring recording | Actual duration of Transcranial-holter monitoring recording (minutes) will be measured (expected duration 4 hours) as a feasibility criterion | Day 0 (inclusion) |
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