Stroke Clinical Trial
Official title:
Micro-embolic Signals Detection With Transcranial HOLter in Acute Ischemic STroke: Yield in the Etiologic woR-kup
In acute ischemic stroke, the identification of an etiology is of major importance to prevent recurrence by providing the best treatment. Because of numerous possible underlying etiologies, the etiological work-up of ischemic stroke includes a wide range of diagnostic tests, which can be invasive, long and expensive. Moreover, many patients receive a diagnosis of undetermined stroke even after all available diagnosis tests are done, precluding optimal treatment.
Asymptomatic MES detected by transcranial doppler have been reported in patient with ischemic
stroke. It has been previously demonstrated that MES predict stroke recurrence and that the
frequency of MES depends on stroke etiology. However, the pattern of MES has never been
correlated to stroke etiology. Transcranial-holter is a novel ambulatory system which allows
prolonged recording (up to 4 hours) leading to an increased detection of MES.
Therefore, transcranial holter with an 4 hour-recording will be performed for consecutive
eligible patients hospitalized in our stroke care unit. During the recording, the patient
will be able to continue their usual activities (eating, walking, speaking and sleeping).
All the included patients will have a classical follow-up at 3, 6 months and 12 months. The
neurologist, blinded to the results of transcranial-holter, will have to prescribe and
analyze the results of diagnostic tests to identify stroke etiology. Stroke etiology will be
established according to the ASCOD classification. Questioning and neurological exam (NIHSS
score) will be performed looking for potential recurrent stroke.
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