Stroke Clinical Trial - Atrial Fibrillation & Premature Atrial Complexes

Status Completed

Clinical Trial Summary

The purpose of this study is to improve secondary prevention of ischemic stroke patients by

1. Estimating prevalence and the prognostic significance of frequent premature atrial complexes in ischemic stroke patients in relation to death, recurrent stroke and atrial fibrillation.

2. Characterize ischemic stroke patients by

1. Echocardiographic characteristics

2. Biochemical markers

3. Plaque composition in the carotid arteries

- in order to improve risk stratification.

Clinical Trial Description

Patients with atrial fibrillation (AF) have a five-fold increased risk of ischemic stroke compared to the general population. Identifying AF can be challenging, but prolonged rhythm monitoring of ischemic stroke patients have shown to enhance detection rates of AF. Therefore it is important to identify predictors of AF to allow targeted screening of patients after ischemic stroke and thereby reduce the recurrent stroke rate. Few former studies have shown an association between excessive numbers of premature atrial complexes (PACs) and AF.

The study population of ischemic stroke patients will at admission undergo following examinations:

1. ECG

2. 48 hours inpatient cardiac telemetry (If not known AF)

3. 24 hours holter monitoring (if not known AF)

4. echocardiogram

5. blood sample

6. CT scan of carotid arteries with contrast made on Dual Energy CT scan.

In the follow-up period, patients will have two visits with 48 hour holter monitoring (after 6 and 12 months, respectively) It will be noticed if patients have any recurrent events, die og developing AF.

The study population will be divided into four groups as follows:

1. patients with new AF at admission

2. patients with known AF

3. patients with frequent PACs

4. patients without frequent PACs. These groups will be compared on baseline characteristics and on outcome as mentioned.

The overall perspective is to make better strategies for detecting occult AF after ischemic stroke to improve secondary stroke prevention care. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02180542
Study type	Observational
Source	Odense University Hospital
Contact
Status	Completed
Phase	N/A
Start date	March 2012
Completion date	October 2016

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Atrial Fibrillation and Premature Atrial Complexes in Patients With Ischemic Stroke. — Pacific

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms