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Splenectomy clinical trials

View clinical trials related to Splenectomy.

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NCT ID: NCT06418256 Recruiting - Splenectomy Clinical Trials

Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations

SPLEENVIVO
Start date: October 16, 2016
Phase:
Study type: Observational

Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response in response to these anomalies, the spleen plays a central role in several diseases affecting blood cells, directly or indirectly. The analysis of the splenic clearance of abnormal cells during ex-vivo perfusions made it possible to clarify the pathogenesis of malaria and the role of the spleen in the adaptive immune response. The study's investigative team wishes to extend these explorations to other human diseases in which the spleen is involved, and to evaluate the preventive or curative potential of substances that can modify the perception of blood cells by the spleen (e.g. monoclonal antibodies directed against circulating cells, among other options).

NCT ID: NCT06363578 Not yet recruiting - Dexmedetomidine Clinical Trials

Different Doses of Dexmedetomidine in External Oblique Intercostal Plane Block in Splenectomy

Start date: April 20, 2024
Phase: N/A
Study type: Interventional

The aim of this study is to compare the analgesic effects of different doses of dexmedetomidine as an adjuvant in external oblique intercostal plane block (EOIPB) in splenectomy.

NCT ID: NCT05304455 Completed - Cirrhosis Clinical Trials

Apixaban Prevents Portal Vein Thrombosis After Laparoscopic Splenectomy and Azygoportal Disconnection

ESAPT
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether Apixaban is effective and safe in Prevention of Portal Vein Thrombosis in Liver Cirrhotic Patients after Laparoscopic Splenectomy and Azygoportal Disconnection

NCT ID: NCT05300516 Completed - Hypertension Clinical Trials

Vagus Nerve-guided Robotic-assisted Splenectomy and Azygoportal Disconnection

VNRSD
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

This study aimed to evaluate whether vagus nerve-guided robotic-assisted splenectomy and azygoportal disconnection is effective and safe, and to determine whether a reduction in the incidence of postoperative complications of the digestive system improves postoperative quality of life compared with conventional robotic-assisted splenectomy and azygoportal disconnection.

NCT ID: NCT04244487 Completed - Hypertension Clinical Trials

Laparoscopic Splenectomy and Azygoportal Disconnection With Intraoperative Endoscopic Variceal Ligation

SVEL
Start date: January 3, 2020
Phase: N/A
Study type: Interventional

This study aimed to evaluate whether synchronous vagus nerve-preserving laparoscopic splenectomy and azygoportal disconnection with intraoperative endoscopic variceal ligation (SVEL) is effective and safe, and to determine whether SVEL can effectively decrease the incidence of postoperative esophageal variceal re-bleeding.

NCT ID: NCT04166656 Recruiting - Splenectomy Clinical Trials

Research Trial Assessing the Immunogenicity and Safety of Three Meningococcal B Vaccine Strategies Among Patients With Asplenia.

SPLEMENGO
Start date: September 15, 2022
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate the immunological response and tolerance of 3 vaccine strategies against meningococcus B, a potentially fatal invasive infection.

NCT ID: NCT03998059 Recruiting - Thrombocytopenia Clinical Trials

Evaluation of Immune Status Before and After Splenectomy in Immune Thrombocytopenia Patients

Start date: January 23, 2019
Phase:
Study type: Observational

Evaluation of immune status before and after splenectomy in immune thrombocytopenia patients.

NCT ID: NCT03396796 Completed - Hypertension Clinical Trials

Modified Vagus Nerve-preserving Laparoscopic Splenectomy and Azygoportal Disconnection

ESVLSD
Start date: April 9, 2018
Phase: N/A
Study type: Interventional

This study aimed to evaluate whether vagus nerve-preserving laparoscopic splenectomy and azygoportal disconnection is effective and safe, and to determine whether a reduction in the incidence of postoperative complications of the digestive system improves postoperative quality of life compared with conventional laparoscopic splenectomy and azygoportal disconnection.

NCT ID: NCT02063763 Completed - Adult Patients Clinical Trials

TPO-mimetics Before Splenectomy in Adult Primary Immune Thrombocytopenia Patients.

ITP0614
Start date: May 14, 2014
Phase:
Study type: Observational

This study aims at analyzing the therapeutic activity of TPO-mimetics Eltrombopag and Romiplostim as bridge therapy for splenectomy in adult patients with primary immune thrombocytopenia.