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Sentinel Lymph Node clinical trials

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NCT ID: NCT03931044 Recruiting - Gastric Cancer Clinical Trials

Fluorescence Image-Guided Lymphadenectomy in Robotic Gastrectomy

IG-MIG
Start date: April 2019
Phase: N/A
Study type: Interventional

Gastric cancer is a worldwide challenge due to its spread, even epidemic in some areas, and the high mortality rates. Lymphadenectomy is considered the fundamental step during radical gastrectomy. In recent years, some researchers have tried to find a way to improve the surgical identification of the lymphatic drainage routes and lymph node stations. This new surgical frontier is the so called "navigation surgery". Among the different reported solutions, lately, the indocyanine green (ICG) has drawn attention. It is a fluorescence dye, that can be detected in the near infrared spectral band (NIR). The development of specific fluorescence imaging devices has allowed surgeons to visualize tumors, vascular and lymphatic structures. The Da Vinci Xi robotic system has an integrated imaging technology that has been used in colo-rectal and hepato-biliary surgery. However, up to date, the combined use of fluorescence imaging and robotic technology has not been evaluated during lymphadenectomy in gastric cancer. The general design of the present study is to evaluate the role of fluorescence imaging during robotic lymphadenectomy for gastric cancer.

NCT ID: NCT03917771 Completed - Sentinel Lymph Node Clinical Trials

Early Detection of Lower Extremity Lymphedema After Lymphadenectomy in Gynecological Cancer

Start date: April 1, 2017
Phase: N/A
Study type: Interventional

This study aims to detect and treat early lower limb lymphedema secondary to lymphadenectomy with the aim of increasing the quality of life of patients with this chronic condition. To this end, a group of patients (treatment group) will be referred to the Rehabilitation service for a previous consultation and after surgery where lymphedema could be detected early. In addition, the usual follow-up will be carried out in Gynecology Oncology consultation (GO). In the second group, also called control, will be performed the usual follow-up in GO. For this we randomize to one of these two groups. The research project has the favorable report of the Center's Clinical Research Ethics Committee

NCT ID: NCT03900104 Recruiting - Endometrial Cancer Clinical Trials

Cervical and Endometrial Injection for Sentinel Lymph Node Detection in Endometrial Cancer

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The investigators think that trans-cervical endometrial tracer injection will cause more paraaortic sentinel lymph node detection. Also, this application is easy, cost-effective and safer than hysteroscopic method. Transtubal tumor spearing will not occur with this method.

NCT ID: NCT03899441 Recruiting - Clinical trials for Perioperative/Postoperative Complications

Multimedia Aid Gynecologic Counseling and Consent

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

This is an interventional trial to introduce two short animated videos into preoperative counseling/consent and to compare patient comprehension and satisfaction with a multimedia approach compared to standard of care currently. The investigators anticipate that patients will retain more information about their surgery and peri-operative care and will be more satisfied with a multimedia approach.

NCT ID: NCT03898687 Recruiting - Melanoma Clinical Trials

The Use of Magtrace®/Sentimag® in Sentinel Node Biopsy for Malignant Melanoma. The Magmen Study.

MAGMEN
Start date: February 1, 2019
Phase: N/A
Study type: Interventional

To evaluate the use of superparamagnetic iron oxide (Magtrace®) as a tracer in sentinel node biopsy in malignant melanoma of the extremities, and to evaluate the possible role of Magtrace®-MRI for staging. Primary objective: • To evaluate if Magtrace®/Sentimag® can be used to identify SN in malignant melanoma with the same diagnostically reliability as the currently used method of Technetium 99m and Patent blue. Secondary objectives: • To evaluate if Magtrace®-MRI can predict sentinel node status in melanoma. This is a feasibility phase I, interventional single arm study. All patients included in the study will receive the same management. 20 patients will be included in the study. An enrollment time of 6-12 months is expected. Primary endpoint • To determine the detection rate of Magtrace®/Sentimag® in comparison to SNB using technetium and blue dye in patients with malignant melanoma of the extremities. Secondary endpoint • To evaluate Magtrace®-MRI sensitivity and specificity as a preoperative tool for staging in malignant melanoma.

NCT ID: NCT03838055 Not yet recruiting - Endometrial Cancer Clinical Trials

Sentinel Node Detection in Endometrial Cancer: A Consolidation Study on Detection Rates of Metastatic Disease

Start date: February 2019
Phase: N/A
Study type: Interventional

Evaluation of removal of Sentinel lymph nodes only for detection of pelvic lymph node metastases in high risk and low risk endometrial cancer.

NCT ID: NCT03779009 Recruiting - Colon Cancer Clinical Trials

Minimally INvasive Colon Cancer Surgery Through IMmunomics and Optical Mapping of the Sentinel Lymph Node.

MINIMAL
Start date: March 1, 2018
Phase: N/A
Study type: Interventional

The project investigates the feasibility of laparoscopic fluorescent imaging for the intraoperative detection of the sentinel lymph node (SLN) in colon cancer patients. In addition, the topology of immunological and microenvironmental changes in normal and invaded lymph nodes (LN's) will be correlated to the LN location (anatomical mapping).

NCT ID: NCT03749707 Recruiting - Cervical Cancer Clinical Trials

HPV in Sentinel Lymph Nodes

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

This study examines sentinel lymph node tissue from early stage cervical cancer patients treated with radical hysterectomy and removal of pelvic sentinel lymph nodes (SLN). SLNs are tested for the presence of human papilloma virus (HPV), and results are compared to the HPV-type found in the patients cervical tissue. We hereby examine whether pathologic status of SLNs in patients with early-stage cervical cancer correlates to the HPV status in the SLNs. By means of an up to 5-years follow-up period, we furthermore examine whether cervical cancer recurrence correlates to the histopathologic status of the SLNs and/or the SLN HPV status. This will contribute to the clarification on whether HPV status of the SLNs plays a crucial role for predicting LN metastasis of cervical cancer and also, whether the HPV status in SLNs may have a clinical value as a prognostic factor for disease recurrence in cervical cancer patients and perhaps even a better clinical value than SLN mapping.

NCT ID: NCT03647631 Completed - Sentinel Lymph Node Clinical Trials

Sentinel Lymph Node Biopsy in Porocarcinoma

Start date: July 17, 2018
Phase:
Study type: Observational

Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both. Histological examination is essential to formulate a correct diagnosis. Surgical excision with clear margins is the standard therapeutic approach while the role of sentinel lymph node biopsy (SNLB) remains controversial. The Authors report two cases of EPC of the lower limbs occurred in two women. Patients were treated by wide surgical excision of the lesion and SNLB.

NCT ID: NCT03640819 Recruiting - Breast Cancer Clinical Trials

Preoperative Tattooing of Biopsied Axillary Node in Breast Cancer

pre-ATNEC
Start date: April 27, 2018
Phase: N/A
Study type: Interventional

The primary aim of this study is to determine whether black ink tattoo injected into the axillary lymph node can be visualized intra-operatively in the same fashion blue sentinel nodes are identified. The second objective is to determine the concordance between tattooed, biopsied axillary lymph node and sentinel node. The third objective is to compare the preoperative pathological assessment on needle biopsy with the histological findings of resected nodes.