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Sentinel Lymph Node clinical trials

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NCT ID: NCT03749707 Recruiting - Cervical Cancer Clinical Trials

HPV in Sentinel Lymph Nodes

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

This study examines sentinel lymph node tissue from early stage cervical cancer patients treated with radical hysterectomy and removal of pelvic sentinel lymph nodes (SLN). SLNs are tested for the presence of human papilloma virus (HPV), and results are compared to the HPV-type found in the patients cervical tissue. We hereby examine whether pathologic status of SLNs in patients with early-stage cervical cancer correlates to the HPV status in the SLNs. By means of an up to 5-years follow-up period, we furthermore examine whether cervical cancer recurrence correlates to the histopathologic status of the SLNs and/or the SLN HPV status. This will contribute to the clarification on whether HPV status of the SLNs plays a crucial role for predicting LN metastasis of cervical cancer and also, whether the HPV status in SLNs may have a clinical value as a prognostic factor for disease recurrence in cervical cancer patients and perhaps even a better clinical value than SLN mapping.

NCT ID: NCT03647631 Completed - Sentinel Lymph Node Clinical Trials

Sentinel Lymph Node Biopsy in Porocarcinoma

Start date: July 17, 2018
Study type: Observational

Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both. Histological examination is essential to formulate a correct diagnosis. Surgical excision with clear margins is the standard therapeutic approach while the role of sentinel lymph node biopsy (SNLB) remains controversial. The Authors report two cases of EPC of the lower limbs occurred in two women. Patients were treated by wide surgical excision of the lesion and SNLB.

NCT ID: NCT03640819 Recruiting - Breast Cancer Clinical Trials

Preoperative Tattooing of Biopsied Axillary Node in Breast Cancer

Start date: April 27, 2018
Phase: N/A
Study type: Interventional

The primary aim of this study is to determine whether black ink tattoo injected into the axillary lymph node can be visualized intra-operatively in the same fashion blue sentinel nodes are identified. The second objective is to determine the concordance between tattooed, biopsied axillary lymph node and sentinel node. The third objective is to compare the preoperative pathological assessment on needle biopsy with the histological findings of resected nodes.

NCT ID: NCT03606616 Active, not recruiting - Breast Cancer Clinical Trials

Prospective Feasibility Study Applying the ACOSOG Z0011 Criteria to Chinese Patients

Start date: August 1, 2015
Study type: Observational [Patient Registry]

In patients undergoing breast-conserving surgery and having positive sentinel lymph nodes (SLNs), the ACOSOG Z0011 trial showed equivalent overall survival(OS) and disease-free survival(DFS) outcomes for patients receiving SLN dissection (SLND) alone and those receiving axillary lymph node dissection (ALND). We conducted a prospective single-arm study to confirm the applicability of the Z0011 criteria to Chinese patients with breast cancer.

NCT ID: NCT03579979 Enrolling by invitation - Breast Cancer Clinical Trials

Sentinel Lymph Node Biopsy in Breast Cancer Surgery Using ICG

Start date: May 31, 2018
Phase: N/A
Study type: Interventional

This clinical trial is a prospective, multicenter, self-controlled clinical study. In order to meet the requirements of this plan, 130 breast cancer patients need the sentinel lymph node biopsy with novel near-infarred fluorescence imaging system produced by Beijing digital precision medical technology co., LTD. The fluorescence molecular imaging of indocyanine green (ICG) on imaging detection and the control group, routine medical using methylene blue test .The safety and efficacy of fluorescence and staining in sentinel lymph node biopsy of breast cancer were compared.

NCT ID: NCT03563781 Recruiting - Sentinel Lymph Node Clinical Trials

SEntine Lymph Node in earLY Ovarian Cancer (SELLY)

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

The present study aims at investigating the feasibility, the detection rate and the negative predictive value of sentinel node in predicting the presence or absence of lymph node metastasis in ovarian cancer patients

NCT ID: NCT03549195 Not yet recruiting - Cervical Cancer Clinical Trials

TMTP1 Targeting Micro-metastasis LN in Laparoscopic SLN Detection in Cervical Cancer

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Investigators aimed to determine the validity of the investigator's novel tumor targeted fluorescent peptide TMTP1-ICG to increased accuracy of laparoscopic SLN mapping

NCT ID: NCT03449615 Recruiting - Sentinel Lymph Node Clinical Trials

Validation of Ferromagnetic Tracer in Melanoma Sentinel Node

Start date: December 21, 2015
Phase: N/A
Study type: Observational

This study has been designed to validate a non-radioactive method to identify the sentinel lymph node using a superparamagnetic iron-oxide (SPIO) tracer respect to the traditional isotopic method. Both methods are used in every included patient and each patient is its own control.

NCT ID: NCT03294330 Enrolling by invitation - Breast Cancer Clinical Trials

SPY-X: A Study to Assess the Feasibility of Using SPY Alone for Sentinel Node Localization for Melanoma or Breast Cancer

Start date: October 11, 2017
Phase: Phase 3
Study type: Interventional

The objective of this study is to determine if fluorescence lymphangiography can be used alone to localize sentinel nodes in patients with melanoma or breast cancer. The hypothesis is that sentinel nodes can be identified using only indocyanine green (ICG) and fluorescence lymphangiography, without the need for technetium99 and a gamma probe.

NCT ID: NCT03123042 Recruiting - Clinical trials for Early Gastric Cancer

Feasibility Study of Sentinel Navigation Surgery After Non-curative Endoscopic Resection

Start date: March 20, 2017
Phase: N/A
Study type: Interventional

Purpose: To prove the feasibility of sentinel node navigation surgery (SNNS) in early gastric cancer patients with the risk of lymph node metastasis after endoscopic resection and preparation of multicenter phase 3 trial of stomach preserving surgery in these patients. Contents: The number of enrollment is 247 patients. The patients underwent endoscopic resection for early gastric cancer, and the tumor was defined to be out of indication for endoscopic resection pathologically. So, additional gastrectomy is recommended for them. The investigators will enroll patients who agree this study. After general anesthesia, Tc99m-Phytate with indocyanine green will be injected with endoscopy. Then sentinel basin will be detected using gamma probe and laparoscopic basin dissection will be done. Sentinel lymph node will be identify in back table dissection, and patients will undergo conventional gastrectomy. Detection rate and false negative rate will be evaluated by pathological review.