Cognitive Effects of Nimodipine in Patients With Schizophrenia

Status Completed

Clinical Trial Summary

This study aims to evaluate the acute effects of nimodipine on cognitive performance in patients with schizophrenia using a battery of cognitive assessments.The subjects will also complete a 30-minute structural and functional MRI scan, with the goal of linking brain activity with working memory performance. Investigators predict that the performance increase induced by nimodipine will be greater in subjects who carry the A allele for the Calcium Voltage-Gated Channel Subunit Alpha1 C (CACNA1C) risk single nucleotide polymorphism (SNP) (rs1006737) in comparison to the response of G carriers.

Clinical Trial Description

The main cognitive task of interest in this study is the N-back task because of the observed attenuation of prefrontal and parietal cortical activity after nimodipine administration in healthy subjects. Investigators hypothesize that acute nimodipine administration will improve cortical activation, which will lead to improved cognitive performance. The current study will provide insight whether nimodipine or another calcium channel blocker could be used as a treatment approach to alleviate cognitive deficits in patients with schizophrenia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03671525
Study type	Interventional
Source	Johns Hopkins University
Contact
Status	Completed
Phase	Early Phase 1
Start date	October 5, 2018
Completion date	May 12, 2023

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