PreTerm Birth Clinical Trial
Official title:
Glucose Monitoring During Threatening Preterm Birth With Particular Focus on Insulin Sensitivity and Glucose Tolerance in Patients With and Without Gestational Diabetes Mellitus
This study aims to show whether the hyperglycaemic phases following a treatment with glucocorticoids, as well as blood measurements correlated to high blood glucose levels and insulin resistance, vary significantly between patients with and without gestational diabetes mellitus.
BACKGROUND:
The therapy with glucocorticoids for fetal lung maturation in the case of threatening preterm
birth is an long existing part of the obstetric routine procedures. Under this therapy it
should not be forgotten, that glucocorticoids can lead to a decrease of the maternal insulin
sensitivity as well as they can cause an impaired maternal glucose tolerance.
Therefore a threatening preterm birth as well as the including medical therapy do challenge
the glucose metabolism of mother and child.
Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy,
and the numbers are on the rise. GDM is characterized through an insulin resistance during
the pregnancy.
High blood glucose level during pregnancy or labour can cause complications like a fetal
hypoglycaemia right after birth.
METHODS:
This study includes pregnant women with and without gestational diabetes who are medicated
with betamethasone due to threatening preterm birth.
In this study the blood glucose measurements of one week, as well as the measurements of
HbA1C, Insulin and Blood Glucose from a blood draw one week after the lung maturation therapy
will be considered.
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