Parenting Skills Group for Mothers With Postpartum Depression

Status Recruiting

Clinical Trial Summary

The goal of this longitudinal study is to study the effects of a parenting skills group (Circle of Security Parenting, aka COSP) in mothers with postpartum depression. The main questions it aims to answer are: - Will changes in methylation of the OXTR rs53576 be apparent in mother and/or infant after having gone through the 8-week COSP program? - Will COSP participation be associated with improved symptoms of postpartum depression (over and above standard care), attachment style, and relational characteristics of the mother-infant dyad? - Will COSP participation be associated with changes in social behavior in the infant, and if so, do they persist throughout childhood? Participants will - Participate in an 8-week COSP program delivered remotely via Zoom. - Provide buccal swabs (mother and infant) to assess changes in methylation of OXTR rs53576 pre- versus post-intervention. - Complete a series of assessment questionnaires delivered remotely. - Videotape a play-based assessment in their home. - Receive infant developmental testing Researchers will compare characteristics of waitlist controls to those participating in the COSP program at the mid-way point of the program to see if the two groups differ.

Clinical Trial Description

The primary aims of this study are to 1) better understand the biological/genetic mechanisms and processes of behavior change in mothers and babies relating to oxytocin receptor gene methylation; 2) complete an outcome assessment of the efficacy of the COSP intervention using a tele-health format, specifically in relation to treating maternal depression; 3) to better understand the mechanisms and processes of change in relation to maternal and infant co-regulation achieved through the promotion of a secure attachment between mothers and their at-risk infants, and to understand how these processes form a trajectory of behavioral outcomes in kindergarten. The COSP program lasts for 8 weeks and will be delivered via Zoom. Researchers will collect a variety of data including biological samples, self-report questionnaires, developmental assessment, and direct observation to assess predictors and outcomes relating to participation in the COSP program. Data will be collected prior to starting COSP, half-way through participation, after having completed the program, and at several timepoints following completion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05772897
Study type	Interventional
Source	University of Colorado, Denver
Contact	Sunny Stophaeros, MS
Phone	9253392971
Email	sunny.stophaeros@ucdenver.edu
Status	Recruiting
Phase	N/A
Start date	August 3, 2023
Completion date	June 1, 2035

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06348316` - Early Half Swaddling and Kangaroo Care Practices on Maternal Sleep Quality and Postpartum Depression in Term Babies	N/A
Completed	`NCT05322161` - Yoga in the NICU for Parents Study	N/A
Withdrawn	`NCT03709004` - Pacifiers and Breastfeeding Among Mothers at Risk for Postpartum Depression	N/A
Completed	`NCT06305325` - Coparenting Intervention to Prevent Postpartum Depression	N/A
Not yet recruiting	`NCT05055674` - The Effects of Motherly on Postpartum Depression	N/A
Enrolling by invitation	`NCT02323152` - PREVENTION OF POSTPARTUM DEPRESSION DEVELOPMENT IN WOMEN WITH VERY HIGH RISK	N/A
Not yet recruiting	`NCT01658098` - Prevalence of Postpartum Depression in Hospital Jose E. Gonzalez	N/A
Completed	`NCT00961402` - The Effect of Exercise on Preventing PostPartum Depression	Phase 2
Completed	`NCT01312883` - Mothers Avoiding Depression Through Empowerment Intervention Trial	N/A
Completed	`NCT00360204` - Improving Health Outcomes for New Mothers and Babies	Phase 3
Unknown status	`NCT00548743` - Translating Research Into Practice for Postpartum Depression	N/A
Completed	`NCT04146025` - Nurtured in Nature	N/A
Not yet recruiting	`NCT06442774` - MamaConecta: Digital Tool for Maternal Mental Health	N/A
Recruiting	`NCT05137925` - Mindful Moms: Mechanisms of Mindfulness-based Cognitive Therapy During Pregnancy and Postpartum	N/A
Not yet recruiting	`NCT05299398` - Prevention of Postpartum Depression: A Pilot Placebo-controlled Trial of Trazodone	Phase 1
Completed	`NCT04925765` - Virtual Reality Biofeedback for Postpartum Anxiety and Depression	N/A
Recruiting	`NCT06053515` - Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication	N/A
Completed	`NCT04037085` - Ketamine to Improve Recovery After Cesarean Delivery - Part 1	Phase 2
Completed	`NCT05059600` - A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting	Phase 4
Completed	`NCT06136520` - The Effect of Baby Massage Training Given to Pregnant Women on Maternal Attachment and Postpartum Depression	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.