Periodontal Diseases Clinical Trial
Official title:
Effects of Non-surgical Periodontal Treatment on the Gingival Crevicular Fluid Cytokine Profiles in Breast Cancer Patients Undergoing Chemotherapy
Aim: This study evaluated the effects of non-surgical periodontal therapy (NSPT) on the
cytokine profile and the correlation to clinical parameters of patients undergoing
chemotherapy for breast cancer.
Materials and methods: 40 patients were allocated: periodontitis patients (P) (n=20) and
breast cancer with periodontitis patients (CAN/P) (n=20). The clinical parameters: probing
depth (PD), clinical attachment level (CAL), plaque index (PI), Bleeding on probing (BOP) and
levels of IFN-γ, IL-4, IL-10, TGF-β, IL-17, IL-2, IL-6, IL-1β and TNF-α in gingival
crevicular fluid (GCF) were evaluated at baseline, 45 and 180 days after therapy.
The NSPT, which consisted of subgingival debridement - scaling and root planning (SRP) under local anesthesia. On average, the treatment of the entire oral cavity was completed within four sessions (sessions of 50 minutes). The SRP was performed by one experienced periodontist (KRVV) using Gracey curettes (Hu-Friedy MFG. Co. Inc., Chicago, IL, USA), ultra-sonic devices (Bob-Cat, Dentsply/Cavitron, Long Island City, NY, USA) and, if necessary, with multilaminated drills. ;
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