Serum Levels of Vitamin D and IL8 in Patients With Periodontitis

Periodontal Diseases Clinical Trial

Official title: Serum Levels of Vitamin D and IL8 in Patients With Periodontitis: A Case-control Study

Status Completed

Clinical Trial Summary

We evaluated vitamin D and IL8 levels in the serum of patients with periodontitis as well as the healthy controls to correlate their levels with the degree of periodontitis.

Clinical Trial Description

The primary objective of this study is to assess the levels of vitamin D and IL8 in the serum of individuals diagnosed with periodontitis and compare them with those of a healthy control group. The study also aims to establish correlations between these serum levels and the degree of periodontitis severity. Two groups will be recruited: patients diagnosed with periodontitis and a control group consisting of individuals without periodontal disease. The participants will be matched for age, gender, and other relevant demographic factors to minimize confounding variables. Serum samples will be collected from both groups. Periodontitis severity will be determined using established clinical indices, such as probing depth, clinical attachment loss, and bleeding on probing. Vitamin D levels in the serum will be measured using standardized laboratory techniques. IL8 levels in the serum will also be quantified using appropriate assays. Statistical analyses will be performed to identify any significant correlations between vitamin D levels, IL8 levels, and the severity of periodontitis. Subgroup analyses may be conducted to explore potential variations based on demographic factors or other relevant variables. The study will adhere to ethical guidelines, ensuring participant confidentiality, informed consent, and responsible data handling. The study anticipates finding associations or correlations between serum levels of vitamin D and IL8 and the severity of periodontitis. This information may contribute to a better understanding of the role of these factors in periodontal health and could have implications for future preventive and therapeutic strategies. ;

Related Conditions & MeSH terms

• Periodontal Diseases
• Periodontitis

• NCT number: NCT06306937
• Study type: Observational
• Source: Mansoura University
• Status: Completed
• Start date: September 1, 2022
• Completion date: September 30, 2023