Periodontal Disease Clinical Trial
Official title:
Estimation of Sialic Acid and IL10 Levels in Stage 1 and 2 Periodontitis Patients
Sialic acid (SA) is the generic term given to a family of acetylated derivatives of
neuraminic acid. SA is a 9 carbon monosaccharide. An important function of host SA is to
regulate innate immunity. SA is present in several acute phase proteins which are known to be
associated with periodontitis. There exists a need for a biomarker, for early detection of
disease evolution and more robust therapy efficacy measurements. Till date, there is very
little data regarding simultaneous estimation and comparison of total SA content in saliva.
IL-10, an anti-inflammatory cytokine, regulates the synthesis of pro-inflammatory cytokines
such as IL-1, -2, -6 and stimulates protective antibody production. IL-10 is expressed in
both healthy and diseased human periodontal tissues and is reported to be reduced in patients
infected with Aggregatibacter actinomycetemcomitans.
The present study was therefore undertaken with an aim, to not only assess the levels of
TSA(Total sialic acid levels),but also of IL 10 levels in saliva from stage 1(mild) to stage
2(moderate) periodontitis patients
Selection of patients by grading the patients according to criteria stage 1 and 2
Periodontitis
Obtaining consent from patients participating in the study
Collection of saliva-unstimulated whole saliva, the samples will be stored at -20 degree
Centigrade and later placed in a 1.5ml centrifuge tubes which will be placed in a vacuum cool
box indicated for laboratory samples and transported to the lab for investigations. It will
be centrifuged at 2500 rpm for 10 mins,stored at -80 deg C. SA(sialic acid) levels will be
determined by thiobarbutic acid method of aminoff and ELISA methods. SA levels will be
measured in mg/dl,IL10 as in direct measurement.
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