Chronic Kidney Disease Clinical Trial
Official title:
Periodontal Disease, Inflammation, Nutritional Status And Anaemia Response To Erythropoietin In Chronic Haemodialyzed Patients - The Impact Of Treatment For Periodontal Disease
Several studies revealed a direct relationship between the severity of periodontal inflammation and CRP (NHANES III, Dumitriu HT et al, 1998). In patients without any other source of inflammation but PDD, proper dental treatment of the disease decreased CRP to normal levels (Dumitriu H.T. et al., 1998; D'Aiuto F. et al, 2004; Borawski J. et al., 2007) Moreover, a direct link between high levels of CRP and atherosclerotic complications has been found in studies conducted both in general population (Ridker PM, et al., 1998; Koenig W, et al., 1999) and in HD subjects (Westhuyzen J, et al., 2000; Iseki K., et al., 1999; Zimmermann J, et al. 1998).
Patients will be recruited according to eligibility criteria. Initial oral and general status
will be evaluated and recorded. The evaluated parameters are listed at the study description
section. Also, quality of life will be assessed by using the SF-36 and OHIP-14
questionnaires.
Patients will undergo a series of dental interventions with the final scope of eliminating
all oral inflammation. Participants will also be instructed regarding correct oral hygiene
habits.
Following dental and periodontal treatments, the oral and general status will be reassessed
and the obtained dat analysed.
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