Body Weight Gain, Parkinson, Subthalamic Stimulation

Status Completed

Clinical Trial Summary

Chronic bilateral subthalamic stimulation leads a spectacular clinical improvement in patients with motor complications. However, the post-operative body weight gain involved may limit the benefits of surgery and induce critical metabolic disorder. The aim of this study to determine the energy expenditure in usual conditions of life.

Clinical Trial Description

Patients will be studied before (between 3 and 1 months) and after (1 month) STN-DBS surgery. Each time the same measurements will be taken. The principal ones will be : - Clinical examination - Autoevaluation dietary questionnaire - Biological tests - Study in calorimetry chamber (only in Clermont-Ferrand centre) - Heart rate recorded during 7 days in usual conditions of life - Energy expenditure recorded during 14 days in usual conditions of life with normalized water (18O 10 %) and Deuterium oxide (99.94 %D) - Acute Ldopa challenge (in both conditions of dopa and stim) - Apathy evaluation - Body weight, and body compositions measurements ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00529724
Study type	Interventional
Source	University Hospital, Clermont-Ferrand
Contact
Status	Completed
Phase	Phase 2
Start date	September 3, 2007
Completion date	June 1, 2018

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