Comparison of Hyaluronidase and Dexametasone in Reduction of Postoperative Edema

Pain Clinical Trial

Official title:

Comparison of the Effects of Hyaluronidase and Dexamethasone on Reduction of Postoperative Edema in Impacted Wisdom Teeth Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05466604
• Other study ID #: YDU/2019//74-921
• Status: Completed
• Phase: Phase 4
• Start date: December 1, 2019
• Est. completion date: June 30, 2022

Study information

• Verified date: July 2022
• Source: Hacettepe University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study is designed to reveal effectiveness of hyaluronidase and dexamethasone on reduction of postoperative edema, pain, trismus, and infection. For this purpose, 60 participants with symmetrical mandibular wisdom teeth enrolled the present study. All measurements and evaluations were performed before and 1, 2, 3, and 7 days later the operation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: June 30, 2022
• Est. primary completion date: June 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• symmetrical mandibular wisdom teeth with bone retention
• patients who are signed informed consent and acceptance of study involvement forms

Exclusion Criteria:

• existence of any systemic disease
• existence of any periodical drug intake
• existence of difference in operation times of right and left impacted wisdom teeth extractions more than 5 minutes
• existence of pregnancy
• existence of breastfeeding

Related Conditions & MeSH terms

• Edema
• Infection, Surgical Site
• Pain
• Surgical Wound Infection
• Trismus

Intervention

Drug:
• Hyaluronidase Injection mesomedica
injection of 150 IU hyaluronidase to perioperative region, submucosally.
• Dexamethasone dekort
injection of 8 mg dexamethasone to perioperative region, submucosally.

Locations

Country	Name	City	State
Cyprus	Near East University	Nicosia
Turkey	Hacettepe University	Ankara	Sihhiye

Sponsors (1)

Lead Sponsor	Collaborator
Hacettepe University

Countries where clinical trial is conducted

Cyprus,  Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase experimental group	preoperative edema amount was subtracted from edema amount in 1. day in hyaluronidase experimental group	postoperative 1. day
Primary	evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase experimental group	preoperative edema amount was subtracted from edema amount in 2. day in hyaluronidase experimental group	postoperative 2. day
Primary	evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase experimental group	preoperative edema amount was subtracted from edema amount in 3. day in hyaluronidase experimental group	postoperative 3. day
Primary	evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase experimental group	preoperative edema amount was subtracted from edema amount in 7. day in hyaluronidase experimental group	postoperative 7. day
Primary	evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase control group	preoperative edema amount was subtracted from edema amount in 1. day in hyaluronidase control group	postoperative 1. day
Primary	evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase control group	preoperative edema amount was subtracted from edema amount in 2. day in hyaluronidase control group	postoperative 2. day
Primary	evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase control group	preoperative edema amount was subtracted from edema amount in 3. day in hyaluronidase control group	postoperative 3. day
Primary	evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase control group	preoperative edema amount was subtracted from edema amount in 7. day in hyaluronidase control group	postoperative 7. day
Primary	evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone experimental group	preoperative edema amount was subtracted from edema amount in 1. day in dexamethasone experimental group	postoperative 1. day
Primary	evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone experimental group	preoperative edema amount was subtracted from edema amount in 2. day in dexamethasone experimental group	postoperative 2. day
Primary	evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone experimental group	preoperative edema amount was subtracted from edema amount in 3. day in dexamethasone experimental group	postoperative 3. day
Primary	evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone experimental group	preoperative edema amount was subtracted from edema amount in 7. day in dexamethasone experimental group	postoperative 7. day
Primary	evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone control group	preoperative edema amount was subtracted from edema amount in 1. day in dexamethasone controlgroup	postoperative 1. day
Primary	evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone control group	preoperative edema amount was subtracted from edema amount in 2. day in dexamethasone controlgroup	postoperative 2. day
Primary	evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone control group	preoperative edema amount was subtracted from edema amount in 3. day in dexamethasone controlgroup	postoperative 3. day
Primary	evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone control group	preoperative edema amount was subtracted from edema amount in 7. day in dexamethasone controlgroup	postoperative 7. day
Primary	evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 1. day using a measuring tape	edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 1. day	postoperative 1. day
Primary	evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 2. day using a measuring tape	edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 2. day	postoperative 2. day
Primary	evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 3. day using a measuring tape	edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 3. day	postoperative 3. day
Primary	evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 7. day using a measuring tape	edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 7. day	postoperative 7. day
Primary	evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 1. day using a measuring tape	edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 1. day	postoperative 1. day
Primary	evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 2. day using a measuring tape	edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 2. day	postoperative 2. day
Primary	evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 3. day using a measuring tape	edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 3. day	postoperative 3. day
Primary	evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 7. day using a measuring tape	edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 7. day	postoperative 7. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase experimental group in postoperative 1. day	pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 1. day	postoperative 1. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase experimental group in postoperative 2. day	pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 2. day	postoperative 2. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase experimental group in postoperative 3. day	pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 3. day	postoperative 3. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase experimental group in postoperative 4. day	pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 4. day	postoperative 4. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase experimental group in postoperative 5. day	pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 5. day	postoperative 5. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase experimental group in postoperative 6. day	pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 6. day	postoperative 6. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase experimental group in postoperative 7. day	pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 7. day	postoperative 7. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase control group in postoperative 1. day	pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 1. day	postoperative 1. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase control group in postoperative 2. day	pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 2. day	postoperative 2. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase control group in postoperative 3. day	pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 3. day	postoperative 3. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase control group in postoperative 4. day	pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 4. day	postoperative 4. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase control group in postoperative 5. day	pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 5. day	postoperative 5. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase control group in postoperative 6. day	pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 6. day	postoperative 6. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in hyaluronidase control group in postoperative 7. day	pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 7. day	postoperative 7. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone experimental group in postoperative 1. day	pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 1. day	postoperative 1. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone experimental group in postoperative 2. day	pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 2. day	postoperative 2. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone experimental group in postoperative 3. day	pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 3. day	postoperative 3. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone experimental group in postoperative 4. day	pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 4. day	postoperative 4. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone experimental group in postoperative 5. day	pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 5. day	postoperative 5. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone experimental group in postoperative 6. day	pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 6. day	postoperative 6. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone experimental group in postoperative 7. day	pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 7. day	postoperative 7. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone control group in postoperative 1. day	pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 1. day	postoperative 1. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone control group in postoperative 2. day	pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 2. day	postoperative 2. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone control group in postoperative 3. day	pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 3. day	postoperative 3. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone control group in postoperative 4. day	pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 4. day	postoperative 4. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone control group in postoperative 5. day	pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 5. day	postoperative 5. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone control group in postoperative 6. day	pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 6. day	postoperative 6. day
Primary	evaluation of the pain using visual analog scale (VAS) and daily count of NSAI drug intake in dexamethasone control group in postoperative 7. day	pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAI drug intake in postoperative 7. day	postoperative 7. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group preoperatively.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	preoperative
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 1. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 1. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 2. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 2. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 3. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 3. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 7. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 7. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group preoperatively.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	preoperative
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 1. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 1. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 2. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 2. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 3. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 3. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 7. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 7. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group preoperatively.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	preoperative
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 1. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 1. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 2. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 2. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 3. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 3. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 7. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 7. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group preoperatively.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	preoperative
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 1. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 1. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 2. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 2. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 3. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 3. day
Primary	evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 7. day.	amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler	postoperative 7. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group preoperatively.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	preoperative
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 1. day.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 1. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 2. day.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 2. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 3. day.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 3. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 7. day.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 7. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group preoperatively.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	preoperative
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 1. day.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 1. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 2. day.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 2. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 3. day.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 3. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 7. day.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 7. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group preoperatively.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	preoperative
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 1. day	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 1. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 2. day	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 2. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 3. day	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 3. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 7. day	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 7. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group preoperatively.	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	preoperatively
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 1. day	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 1. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 2. day	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 2. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 3. day	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 3. day
Primary	evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 7. day	existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.	postoperative 7. day