View clinical trials related to Overweight.
Filter by:The purpose of this study is to compare the use of personalized low-fat meal plans vs. non-personalized low-fat meal plans and the results in body fat reduction in overweight and obese subjects 25 to 45 years of age. Compensation to Eligible Participants: 1. FREE Nutritional Services will be provided to eligible participants, which normally have a business value of between $165.00 and $195.00. 2. Each eligible participant will receive compensation for mileage directly related to this study up to 35 miles at the 2007 IRS Business Mileage Reimbursement Rate for medical purposes of $0.20 per mile. This compensation will be provided to each eligible participant in the form of a complimentary Wal-mart Gift Card in the amount of $7.00, contingent upon his or her completion in the study.
This study will describe the phenotype (physical and behavioral traits) of overweight and obese people. It will characterize the hormones, metabolism, food preferences, fitness and physical activity levels, sleep patterns and thought processes in people with and without weight problems. Genetic material will be collected for studies of the internal codes that influence body weight. People over 18 years of age from all weight categories (lean, overweight, obese) who are reasonably healthy may be eligible for this study. Participants undergo the following tests and procedures: - Physical exam, electrocardiogram, blood and urine tests, instructions for recording food intake for 7 days - Metabolic studies for menstruating women. - Resting metabolic rate to study how many calories the body burns at rest. - Mixed meal test to measure hormones such as insulin that regulate blood sugar. - Glucose tolerance test to determine how sensitive the body is to insulin. - 24-hour energy expenditure to measure the amount of oxygen breathed in and the amount of carbon dioxide breathed out. - Repeat 24-hour energy expenditure. - Diurnal blood sampling and temperature assessment to study the body s internal clock. - Air-displacement plethysmography (Bod Pod) to measure body composition. - Dual energy x-ray absortiometry (DEXA) to measure body fat and bone density. - Repeat Bod Pod and DEXA. - Anthropometric measurements and bioelectrical impedance to measure height, weight, and circumferences, skinfold thickness, fluid status and percentage body fat. - Bromide dilution to measure the amount of water not in cells in the body. - Doubly labeled water to measure the amount of calories burned in a 7-day period. - 24-hour diet reports. - Endothelial reactivity to measure how the blood vessels stretch or dilate for assessing cardiovascular health. - Treadmill or bicycle exercise capacity test. - Physical activity monitor. - Unicorder to detect any breathing difficulties that may interfere with sleep. - Fat and muscle biopsy to look for variations in gene expression in fat tissue and muscle. - Neurocognitive testing to check memory, decision-making, hand-eye coordination, and reasoning. - Evaluation of mood problems and assess personality type. - Evaluation to assess the quantity and quality of pain experienced. - Taste testing to determine the response to bitter, salty, sweet and sour substances. - Occupational therapy evaluation to explore the subject s adaptations, if any, for performing personal, social or professional activities; the subject s views on his or her weight, body size and shape, and strategies to control weight.
To determine the extent to which a clinical intervention based on the Chronic Care Model (CCM), compared with the usual care control condition, results in a smaller age-associated increase in body mass index (BMI) over a 1 year intervention (primary outcome) and a 1 1/2-year follow-up period.
Obesity has reached epidemic proportions with nearly two-thirds of the US population either overweight or obese. Thus, novel strategies that both improve weight loss maintenance and are accessible to those most in need are the focus of this application, which will determine if a telemedicine system can help participants, who have undergone a weight loss program based in church and community centers, maintain their weight loss over a 1 year period. Telemedicine will provide support through self-monitoring, education, supervised chat room, bulletin board, and e-mail.
The prevalence of obesity in the United States has reached alarming proportions with 33% of adults over the age of 20 being overweight. Obesity is more than twice as prevalent, however, in the Pima Indians of Arizona. Although there have been a number of advances in our understanding of the genetics of obesity, the environmental influences on the genetic expression of obesity requires further investigation. In an effort to understand some of the influences on the high prevalence of obesity in the Pima Indians, the present study was designed to investigate eating behaviors and food preferences, most especially the preference for high fat foods, in sib-pairs of Pima Indians who have been previously genotyped in our genomic scan for loci linked to diabetes/obesity. Most specifically, we will utilize several questionnaires and methods of assessing eating behavior and the preference for high fat foods to create a food intake phenotype. In addition, we will study Caucasians so that comparisons can be made between these two groups. We will make these evaluations by assessing eating behavior, food preferences including usual fat intake and preferences for high fat foods, body image perceptions, and energy expenditure. It is hoped that the data gathered from this study will elucidate some of the risk factors for the development of obesity among the Pima Indians....
This study is looking at overweight patients with chronic heart failure (CHF), to compare the effects of a modified fat diet with a reduced glycaemic load (diet 1); and a conventional low fat, high carbohydrate diet (diet 2) on: - insulin sensitivity (using the homeostasis model assessment [HOMA] model) - lipid profile - symptomatic status (6 minute walk distance and Heart Failure Quality of Life [HF QOL] Questionnaire) - body weight - inflammatory mediators (tumor necrosis factor [TNF] alpha, C-reactive protein [CRP], interleukin-6 [IL-6]) The hypotheses of this study are: - Diet 1 will be associated with lower insulin resistance than diet 2. - The lipid profile will be better in CHF patients on diet 1 than on diet 2. - Patients on diet 1 will have a better symptomatic status than patients on diet 2. - Diet 1 will maintain body weight in patients with CHF as well as diet 2. - Diet 1 will suppress the expression of TNF-alpha, CRP and IL-6 more than diet 2.