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Optimal Reperfusion Strategy for STEMI Patients With Anticipated PPCI Delay

ST Elevation Myocardial Infarction Clinical Trial

Official title:
A Prospective Randomized Multi-center Clinical Trial Comparing Different Fibrinolysis-transfer Percutaneous Coronary Intervention Strategies in Acute ST-segment Elevation Myocardial Infarction

Clinical Trial Summary

The OPTIMAL-REPERFUSION trial will help determine whether reduced-dose facilitated PCI strategy improves clinical outcomes in patients with STEMI and anticipated PPCI delay

Clinical Trial Description

OPTIMAL-REPERFUSION is an investigator-initiated, prospective, multicenter, randomized, open-label, superiority trial with blinded evaluation of outcomes. A total of 632 STEMI patients presenting within 6 hours after symptom onset and with an expected time of medical contact to percutaneous coronary intervention ≥120 min will be randomized to a reduced-dose facilitated PCI strategy (reduced-dose fibrinolysis combined with simultaneous transfer for immediate invasive therapy with a time interval between fibrinolysis to PCI < 3 hours) or to pharmacoinvasive treatment. The primary endpoint is the composite of death, reinfarction, refractory ischemia, congestive heart failure, or cardiogenic shock at 30-days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04752345
Study type Interventional
Source West China Hospital
Contact Yong He
Phone +86 13981919366
Email heyong_huaxi@163.com
Status Not yet recruiting
Phase N/A
Start date March 2021
Completion date September 2023
View Details
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