Attention Bias Modification Treatment for Major Depressive Disorder in Adolescents

Major Depressive Disorder, Single Episode, Unspecified Clinical Trial

Official title:

Attention Bias Modification Treatment for Major Depressive Disorder in Adolescents: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02078258
• Other study ID #: 1
• Status: Completed
• Phase: N/A
• Start date: September 2012
• Est. completion date: July 2015

Study information

• Verified date: March 2019
• Source: Hunan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In this study, we test whether a two-week 8-session neutral attention bias modification (ABM) training and a two-week 4-session positive ABM could reduce depressive symptoms relative to placebo controls in adolescents with major depressive disorder at posttraining and follow-ups during one year.

Description:

Depression is a common health problem in adolescents. Negative attentional bias has been theorized to play a critical role in the onset and maintenance of depression, suggesting that reduction of such biases may treat symptoms of depression. Recent studies have shown that attention bias modification(ABM) training could reduce depressive symptoms in both dysphoria and previously depressed adult patients.To test the effectiveness of ABM training on the treatment of depressive symptoms in depressed adolescents, we designed a randomized, double-blind, placebo controlled trial in adolescents with major depressive disorder(MDD).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 45
• Est. completion date: July 2015
• Est. primary completion date: January 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 11 Years to 19 Years

Eligibility

Inclusion Criteria:

• Meet the major depression disorder's criteria

Exclusion Criteria:

• bipolar disorder, schizophrenia or organic mental disorder;

• any concurrent psychotherapy;

• any concurrent psychotropic medication.

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Disease
• Major Depressive Disorder, Single Episode, Unspecified

Intervention

Behavioral:
• ABMT
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition.

Locations

Country	Name	City	State
China	Department of Psychology, Hunan Normal University	Changsha	Hunan

Sponsors (1)

Lead Sponsor	Collaborator
Hunan Normal University

Country where clinical trial is conducted

China, 

References & Publications (1)

Yang W, Zhang JX, Ding Z, Xiao L. Attention Bias Modification Treatment for Adolescents With Major Depression: A Randomized Controlled Trial. J Am Acad Child Adolesc Psychiatry. 2016 Mar;55(3):208-18.e2. doi: 10.1016/j.jaac.2015.12.005. Epub 2015 Dec 23. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in depressive symptom number	Depressive symptom accounts measured by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children.	baseline, 7-week, 6-month follow-up
Primary	Changes in depressive severity	depressive severity measured by the construct interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children(K-SADS)	baseline, 7-week, 6-month follow-up
Secondary	Change of Self-report symptoms	symptoms measured by the Center for Epidemiological Studies Depression Scale (CES-D), State-Trait Anxiety Inventory-Trait(STAI-T),Rumination Response Style(RRS),Suicidal Ideation Questionnaire(SIQ)	baseline, 7-week, 6-, 12-month follow-up
Secondary	Diagnostic status of major depressive disorder	Assessed by the diagnostic interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children	baseline, 7-week, 6-month follow-up