Pulmonary Disease, Chronic Obstructive Clinical Trial
— COPDGeneOfficial title:
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease
Verified date | February 2023 |
Source | Brigham and Women's Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD more than others.
Status | Active, not recruiting |
Enrollment | 10718 |
Est. completion date | December 2027 |
Est. primary completion date | December 2027 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 45 Years to 80 Years |
Eligibility | Inclusion Criteria: - At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also being enrolled) - Self-designation of non-Hispanic white or African-American Exclusion Criteria: - Other lung diseases (except for asthma in participants with COPD) - Pregnant - Cancer (other than skin cancer) in the 5 years prior to study entry - Received antibiotics for a COPD exacerbation in the 1 month prior to study entry - First- or second-degree relative of a previously enrolled study participant |
Country | Name | City | State |
---|---|---|---|
United States | Ann Arbor VA Medical Center | Ann Arbor | Michigan |
United States | University of Michigan | Ann Arbor | Michigan |
United States | Morehouse School of Medicine | Atlanta | Georgia |
United States | Johns Hopkins University | Baltimore | Maryland |
United States | University of Alabama at Birmingham | Birmingham | Alabama |
United States | Brigham and Women's Hospital | Boston | Massachusetts |
United States | National Jewish Health | Denver | Colorado |
United States | Duke University | Durham | North Carolina |
United States | Baylor College of Medicine | Houston | Texas |
United States | Houston VA Medical Center | Houston | Texas |
United States | University of Iowa | Iowa City | Iowa |
United States | HealthPartners Research Foundation | Minneapolis | Minnesota |
United States | Minneapolis VA Medical Center | Minneapolis | Minnesota |
United States | University of Minnesota | Minneapolis | Minnesota |
United States | Columbia University Medical Center | New York | New York |
United States | Temple University | Philadelphia | Pennsylvania |
United States | University of Pittsburgh | Pittsburgh | Pennsylvania |
United States | University of Texas Health Sciences Center at San Antonio | San Antonio | Texas |
United States | University of California at San Diego | San Diego | California |
United States | Los Angeles Biomedical Research Institute | Torrance | California |
United States | Fallon Clinic | Worcester | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Brigham and Women's Hospital | National Heart, Lung, and Blood Institute (NHLBI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Forced expiratory volume in 1 second (FEV1) | Measured at baseline | ||
Primary | Emphysema, as shown on chest CT scan | Measured at baseline | ||
Primary | Airway wall thickness on chest CT scan | Measured at baseline | ||
Primary | COPD status (COPD participants versus control group participants) | Measured at baseline |
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