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Lung Diseases, Obstructive clinical trials

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NCT ID: NCT03842904 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease (COPD)

A Study Comparing the Effects of Trimbow to Fostair in COPD

TRIFLOW
Start date: December 13, 2018
Phase: Phase 4
Study type: Interventional

A randomised, open label 2-way cross-over study to compare the effects of inhaled Beclometasone/Formoterol/Glycopyrronium (TRIMBOW) pMDI to Beclometasone/Formoterol (FOSTAIR) pMDI on hyperinflation and expiratory flow limitation in moderate to severe chronic obstructive pulmonary disease (COPD).

NCT ID: NCT03836677 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease (COPD)

A Study to Evaluate the Effects of BGF and GFF on Specific Image Based Airway Volumes and Resistance in Subjects With Moderate to Severe COPD

Start date: February 15, 2019
Phase: Phase 3
Study type: Interventional

This is a randomised, controlled, two period cross-over, 4 weeks chronic dosing, study to evaluate the effects of Budesonide/Glycopyrronium/Formoterol Fumarate (BGF) and Glycopyrronium/Formoterol Fumarate (GFF) on airway dimensions.

NCT ID: NCT03824834 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Morphine to Maximize the Benefits of Exercise Training in COPD or ILD and Persistent Breathlessness

MorEx
Start date: March 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to explore the role of low-dose immediate-release oral morphine as a novel adjunct pharmacotherapy to enable symptomatic adults with advanced chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD) to exercise at higher intensities for longer durations and maximize the psycho-physiological benefits of a supervised exercise training program. We hypothesize that, compared to placebo, exercise training with oral morphine will result in relatively greater improvements in exercise endurance time and intensity ratings of perceived breathlessness during constant-load cardiopulmonary cycle exercise testing (CPET) at 75% of peak power output (PPO).

NCT ID: NCT03823443 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

COPD Exacerbation Blood and Urine Biomarkers Study

Start date: June 7, 2018
Phase:
Study type: Observational

This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population. Serum and urine biomarkers at baseline and after COPD exacerbations will be assessed against change in lung function as measured by pulmonary function testing.

NCT ID: NCT03821311 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function

INVENT
Start date: December 6, 2018
Phase: N/A
Study type: Interventional

This study aims to assess the effect of nasal high flow oxygen therapy on regional function measured by volumetric computed tomography, in patients with chronic obstructive pulmonary disease.

NCT ID: NCT03821285 Recruiting - Clinical trials for Lung Diseases, Obstructive

Respiratory Function in Patients With Post-tuberculosis Lung Impairment

Start date: February 14, 2019
Phase: N/A
Study type: Interventional

Pulmonary tuberculosis (TB) is an important risk factor for chronic respiratory disease due to residual lung damage. A recent review of the literature on TB sequelae and rehabilitation has provided clear evidence that TB is definitively responsible for lung function impairment. Functional evaluation of TB patients after completion of pulmonary tuberculosis treatment or spontaneous healing should be considered as part of clinical care. Unfortunately, few studies are available in the literature investigating the physiopathology of lung damage, its impact on quality of life, the potential need for pulmonary rehabilitation (PR), and the effects of a PR program.Objectives of this prospective multicentre international study are: Primary Objective-to assess the exercise capacity 6-min walking test in patients with post-TB lung impairment after completion of pulmonary tuberculosis treatment or after spontaneous healing. Secondary Objectives-to assess the effects of the PR program on dyspnoea symptoms and muscle fatigue, quality of life.

NCT ID: NCT03819517 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease

Start date: February 2019
Phase: N/A
Study type: Interventional

Researchers have found a link between chronic obstructive pulmonary disease (COPD) and heart disease; however, a link is all they have found. Cardiovascular health in COPD is controlled by different mechanisms including vascular health and systemic inflammation. The investigators have collected preliminary data to support that concentrations of Sirtuin 1 (Sirt1), a protein that plays a key role in cardioprotection, may be involved in cardiovascular health in patients with COPD. Resveratrol, an over the counter natural polyphenol found in a variety of food, is a direct activator of Sirt1 and has been used to improve cardiovascular health in different cohorts. The current project is an attempt to expand previous findings and explore the effects of the sub-chronic use of resveratrol in sustaining the improvements in cardiovascular health in COPD.

NCT ID: NCT03813810 Not yet recruiting - Asthma Clinical Trials

Impact of Air Pollution on Chronic Respiratory Diseases

Start date: January 25, 2019
Phase:
Study type: Observational

The aim of this study is to evaluate the impact of air pollution on the occurrence and clinical course of chronic respiratory diseases, and discover new biomarkers from various devices such as CT images that can indicate the process and amount of lung damage caused by air pollution. Accordingly, the investigators have designed an prospective cohort with enrollment of normal people and patients with chronic respiratory diseases of three different categories (chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis). Participants will be followed up for a period of one year, with evaluation of the clinical course of the respiratory disease and exposure to air pollution.

NCT ID: NCT03811158 Not yet recruiting - Clinical trials for Respiratory Insufficiency

The Edi Level and Cardiopulmonary Function Between HHHFNC and Unheated Humidified High-Flow Oxygen Mask in COPD

Start date: February 28, 2019
Phase: N/A
Study type: Interventional

Patients with COPD exacerbation usually need respiratory support after extubation. Recently, HHHFNC has been used in both adult and neonates with post-extubation respiratory support. Studies indicate that HHHFNC has seminar efficacy compared to non-invasive positive pressure ventilation and superior than conventional oxygen therapy. There are no clinical data of diaphragm electrical activity and cardiopulmonary function for using HHHFNC and UHFOM as post-extubation respiratory support.

NCT ID: NCT03806868 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Dietary Intervention Increasing Omega-3 Intake

Start date: January 2019
Phase: N/A
Study type: Interventional

This Dietary Intervention is being done to evaluate the feasibility of a food voucher program and dietary counseling to increase consumption of healthy fatty acids (omega-3) in individuals with Chronic Obstructive Pulmonary Disease (COPD).