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Emphysema clinical trials

View clinical trials related to Emphysema.

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NCT ID: NCT03114020 Recruiting - Emphysema Clinical Trials

Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency

Start date: March 22, 2017
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the safety and efficacy of administering repeated doses of Hyaluronic Acid Inhalation Solution to subjects with Emphysema that have Alpha-1-Antitrypsin deficiency

NCT ID: NCT03111888 Not yet recruiting - Clinical trials for Pulmonary Disease, Chronic Obstructive

Evaluating the Clinical Effectiveness of 3D Printing for a Patient-specific Silicone Stent Airway Implant

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

The goal of the small feasibility trial is to establish a method, material, and patient-specific design that is superior to what is in use today. The first round of patients are well known to the physician investigator and are familiar with the problem that is being resolved. The end goal of the project is to create a new patient-specific design that will last longer, fit better, and cause less trauma to the airway and the patient.

NCT ID: NCT03073798 Active, not recruiting - COPD Clinical Trials

The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis

Start date: March 18, 2013
Phase: Phase 4
Study type: Interventional

Specific Aim: To determine the effectiveness of Roflumilast in improving i) whole right lung and ii) peripheral right lung mucociliary clearance (MCC) in patients with COPD and chronic bronchitis. Hypothesis: Roflumilast increases mucociliary clearance in patients with chronic bronchitis. Study Design: This will be a double-blinded, cross-over randomized controlled trial with 1:1 randomization of 20 individuals with chronic bronchitis. Subjects will undergo baseline MCC then will be randomized to either roflumilast or placebo x 4 weeks, then there will be a 4 week wash-out phase and a second 4 week period of roflumilast/placebo depending on initial randomization. MCC will be conducted at baseline and at the end of each 4 week medication phase.

NCT ID: NCT03049202 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage Study

BRONCOSCAPIS
Start date: February 1, 2017
Phase: N/A
Study type: Observational

Obstructive lung disease is an increasing global health problem of pandemic proportions, with COPD alone affecting >10% of the population. Smoking is the main and most well studies risk factor for developing COPD. However, chronic airway obstruction also in never-smoking populations has recently been recognized as an increasing health problem. In the clinical segment (PI: Prof. C. Magnus Skold), 1000 subjects from the Swedish national SCAPIS study will be clinically well characterized in one of the six Swedish University Hospital Respiratory clinics (clinical site PIs: Anders Andersson, Leif Bjermer, Anders Blomberg, Christer Janson, Lennart Persson, Magnus Skold). This first screening includes all never-smokers with COPD identified in the SCAPIS study. A subset of 300 subjects from the groups of Healthy never-smokers, current-smokers with normal lung function, current-smokers with COPD, ex-smokers with COPD, and never-smokers with COPD will be selected for the Bronchoscopy segment, were sampling will be performed from a number of anatomical locations, including bronchial biopsies, airway epithelial brushings, and bronchoalveolar lavage. Serum, plasma, and urine samples will also be collected. In the systems medicine segment (PI: Assoc. prof Asa M. Wheelock), alterations at the epigenetic, mRNA, microRNA, proteome, metabolome and microbiome level will be performed from multiple lung compartments (airway epithelium, alveolar macrophages, exosomes, and bronchoalveolar exudates). By means of biostatistics and bioinformatics approaches, specific mediators and molecular pathways critical in the pathological mechanisms of obstructive lung disease related to never-smoker disease phenotypes will be identified. In the immunohistochemistry segment (PI: Prof. Jonas Erjefalt), a number of molecules of relevance for disease pathology will be investigated in bronchial biopsies collected from the 300 subjects in the Bronchoscopy segment.

NCT ID: NCT03034421 Recruiting - Pneumothorax Clinical Trials

Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema

Start date: September 2016
Phase: N/A
Study type: Interventional

Endoscopic valve therapy is an effective therapy for patients with severe emphysema and low interlobar collateral ventilation. Although, valve therapy is a minimal-invasive treatment approach, it is associated with complications the most common of which is pneumothorax with a rate of 18-25%. Modifying post-operative medical care including bed rest for 48 hours after valve implantation may reduce the risk of post-interventional pneumothorax.

NCT ID: NCT03010592 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD

COPD-ENVIRON
Start date: January 2017
Phase: N/A
Study type: Observational

Studying the airway microenvironment in patients undergoing surgical and bronchoscopic interventions for COPD

NCT ID: NCT03010566 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Lung Volume Reduction Coil Microbiome Study

LVRC-Micro
Start date: January 2017
Phase: N/A
Study type: Observational

Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema

NCT ID: NCT03010449 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves

BLOOD-VALVES
Start date: February 2017
Phase: Phase 2/Phase 3
Study type: Interventional

A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves.

NCT ID: NCT03008915 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency

Start date: January 2017
Phase: Phase 2
Study type: Interventional

The aim of this study is to test whether therapies in alpha-1 antitrypsin deficiency-associated lung disease improve endothelial function, measured by pulmonary microvascular blood flow on magnetic resonance imaging (MRI) and with apoptotic endothelial microparticles.

NCT ID: NCT03008226 Recruiting - Emphysema Clinical Trials

Spiration Valve System 9 mm European Post Market Evaluation Study

Start date: June 2015
Phase: N/A
Study type: Observational

The purpose of this observational study is to investigate the efficacy of 9 mm intrabronchial valve treatment in patients with heterogeneous emphysema and to gain further insights and experience on the treatment with this valve size.