Clinical Trials Logo

Emphysema clinical trials

View clinical trials related to Emphysema.

Filter by:

NCT ID: NCT03049202 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage Study

BRONCOSCAPIS
Start date: February 1, 2017
Phase: N/A
Study type: Observational

Obstructive lung disease is an increasing global health problem of pandemic proportions, with COPD alone affecting >10% of the population. Smoking is the main and most well studies risk factor for developing COPD. However, chronic airway obstruction also in never-smoking populations has recently been recognized as an increasing health problem. In the clinical segment (PI: Prof. C. Magnus Skold), 1000 subjects from the Swedish national SCAPIS study will be clinically well characterized in one of the six Swedish University Hospital Respiratory clinics (clinical site PIs: Anders Andersson, Leif Bjermer, Anders Blomberg, Christer Janson, Lennart Persson, Magnus Skold). This first screening includes all never-smokers with COPD identified in the SCAPIS study. A subset of 300 subjects from the groups of Healthy never-smokers, current-smokers with normal lung function, current-smokers with COPD, ex-smokers with COPD, and never-smokers with COPD will be selected for the Bronchoscopy segment, were sampling will be performed from a number of anatomical locations, including bronchial biopsies, airway epithelial brushings, and bronchoalveolar lavage. Serum, plasma, and urine samples will also be collected. In the systems medicine segment (PI: Assoc. prof Asa M. Wheelock), alterations at the epigenetic, mRNA, microRNA, proteome, metabolome and microbiome level will be performed from multiple lung compartments (airway epithelium, alveolar macrophages, exosomes, and bronchoalveolar exudates). By means of biostatistics and bioinformatics approaches, specific mediators and molecular pathways critical in the pathological mechanisms of obstructive lung disease related to never-smoker disease phenotypes will be identified. In the immunohistochemistry segment (PI: Prof. Jonas Erjefalt), a number of molecules of relevance for disease pathology will be investigated in bronchial biopsies collected from the 300 subjects in the Bronchoscopy segment.

NCT ID: NCT03034421 Recruiting - Pneumothorax Clinical Trials

Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema

Start date: September 2016
Phase: N/A
Study type: Interventional

Endoscopic valve therapy is an effective therapy for patients with severe emphysema and low interlobar collateral ventilation. Although, valve therapy is a minimal-invasive treatment approach, it is associated with complications the most common of which is pneumothorax with a rate of 18-25%. Modifying post-operative medical care including bed rest for 48 hours after valve implantation may reduce the risk of post-interventional pneumothorax.

NCT ID: NCT03010592 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD

COPD-ENVIRON
Start date: January 2017
Phase: N/A
Study type: Observational

Studying the airway microenvironment in patients undergoing surgical and bronchoscopic interventions for COPD

NCT ID: NCT03010566 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Lung Volume Reduction Coil Microbiome Study

LVRC-Micro
Start date: January 2017
Phase: N/A
Study type: Observational

Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema

NCT ID: NCT03010449 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves

BLOOD-VALVES
Start date: February 2017
Phase: Phase 2/Phase 3
Study type: Interventional

A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves.

NCT ID: NCT03008915 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency

Start date: January 2017
Phase: Phase 2
Study type: Interventional

The aim of this study is to test whether therapies in alpha-1 antitrypsin deficiency-associated lung disease improve endothelial function, measured by pulmonary microvascular blood flow on magnetic resonance imaging (MRI) and with apoptotic endothelial microparticles.

NCT ID: NCT03008226 Recruiting - Emphysema Clinical Trials

Spiration Valve System 9 mm European Post Market Evaluation Study

Start date: June 2015
Phase: N/A
Study type: Observational

The purpose of this observational study is to investigate the efficacy of 9 mm intrabronchial valve treatment in patients with heterogeneous emphysema and to gain further insights and experience on the treatment with this valve size.

NCT ID: NCT02999685 Enrolling by invitation - Clinical trials for Chronic Obstructive Pulmonary Disease

Home-based Health Management of Chronic Obstructive Lung Disease (COPD) Patients

Start date: September 2016
Phase: N/A
Study type: Interventional

Regular physical activity has been found to be important in maintaining health and well-being in people with COPD. The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more physically active in their daily lives.

NCT ID: NCT02996149 Recruiting - Emphysema Clinical Trials

Endoscopic Lung Volume Reduction Coil Treatment in Patients With Chronic Hypercapnic Respiratory Failure

Start date: November 2016
Phase: N/A
Study type: Observational

Endoscopic lung volume reduction coil treatment is a treatment option for selected patients with severe emphysema. In the advanced stages, emphysema may lead to chronic hypercapnic respiratory failure. In this observational study the safety and efficacy of endoscopic lung volume reduction coil treatment in patients with chronic hypercapnic respiratory failure is evaluated.

NCT ID: NCT02935452 Not yet recruiting - COPD Clinical Trials

Implementing and Evaluating the Genie Tool in COPD

GeCop
Start date: November 2016
Phase: N/A
Study type: Interventional

The Generating Engagement in Network Involvement (GENIE) Tool is designed to support people to find and join social activities in their own neighbourhoods. Evidence has shown that people with more social support have increased ability to manage long term conditions and ill health. Patients with Chronic Obstructive Lung Disease (COPD) have difficulty breathing every day; this is both tiring and makes its difficult to socialise as they did prior to having their condition. COPD can be managed with medicines, and exercise, but will never be cured, so it is considered a 'long term condition.' This study plans to use a social mapping tool (GENIE) with COPD patients that are already part of the community service. The aim of the study is to increase opportunities to socialise and get day to day support outside of the health service. Patients will be offered either the tool, or usual care. If the study is successful then use of health care may reduce in the COPD patients already using the COPD service.