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Emphysema clinical trials

View clinical trials related to Emphysema.

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NCT ID: NCT02810327 Recruiting - COPD Clinical Trials

Alpha-1 Carrier Genomics Study

Start date: February 2015
Phase: N/A
Study type: Observational

The goal of this study is to better understand why some Alpha-1 genotype MZ (PiMZ) individuals develop chronic obstructive pulmonary disease (COPD) while others do not. This study will examine portions of the Alpha-1 gene that are not routinely tested to determine whether other changes in this gene correlate with development and progression of COPD. Participation involves responding to questionnaires about lung health and history, and performing an at-home finger stick to obtain blood spots using a test kit that is mailed. The blood provided will be used for genetic testing and correlation of results with COPD history. Participants will receive their results and access to genetic counseling at the conclusion of the study.

NCT ID: NCT02805699 Recruiting - Clinical trials for Combined Pulmonary Fibrosis and Emphysema

A Clinical Evaluation of Baofeikang Granule in Combined Pulmonary Fibrosis and Emphysema Treatment

Start date: June 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to confirm the efficacy and safety of BaofeiKang Granule in the treatment of Combined Pulmonary Fibrosis and Emphysema patients.

NCT ID: NCT02803242 Recruiting - Emphysema Clinical Trials

COPD Patient-Powered Research Network

COPD PPRN
Start date: August 2014
Phase: N/A
Study type: Observational [Patient Registry]

The COPD Patient-Powered Research Network (COPD PPRN) is a patient research registry with the goal of enrolling 75,000 or more COPD patients and those at risk who are willing to share their heath information over several years and participate in research. The COPD PPRN has built an online platform to allow volunteers to enroll electronically, complete surveys, be contacted about studies they qualify for and become connected to COPD resources. The goal of the registry is to speed research to find better treatments for COPD and ultimately a cure.

NCT ID: NCT02778802 Not yet recruiting - Clinical trials for Pulmonary Hypertension

Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR

Start date: June 2016
Phase: N/A
Study type: Observational

This study is designed as a prospective study, with the primary endpoint being changes in pulmonary hemodynamic parameters after ELVR in patients with severe emphysema. Secondary endpoints will be changes in lung function parameters, exercise capacity, and QoL.

NCT ID: NCT02719184 Recruiting - Clinical trials for Pulmonary Disease, Chronic Obstructive

Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)

Start date: April 2016
Phase: N/A
Study type: Observational

The study will include 125 healthy subjects (ex-smoker without any airflow limitation), 125 COPD GOLD (global initiative for chronic obstructive lung disease) I , 125 COPD GOLD II, 125 COPD GOLD III and up to 40 (with a minimum of 20) patients with COPD and A1AT (Alpha1-Antitrypsin) deficiency (ZZ genotype). Soluble and imaging biomarkers will be investigated addressing different aspects of disease pathways postulated to be relevant for COPD progression.

NCT ID: NCT02713347 Not yet recruiting - Heart Failure Clinical Trials

Advancing Symptom Alleviation With Palliative Treatment

ADAPT
Start date: June 2016
Phase: Phase 3
Study type: Interventional

Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are common serious illnesses. Despite disease-specific medical care for CHF and COPD, people with either illness are often left with poor quality of life (i.e., burdensome symptoms, impaired function). Furthermore, while CHF and COPD are leading causes of hospitalization and mortality, few people with either illness engage in advance care planning, the process of considering and communicating healthcare values and goals. The investigators are conducting a randomized clinical trial to study a symptom management, psychosocial care and advance care planning intervention to improve quality of life. The study is important because it aims to improve quality of life and provision of care according to peoples' goals and preferences in common, burdensome illnesses. Furthermore, this study will generate information that supports the broader dissemination and implementation of the intervention and informs the development of future palliative care and team-based interventions in the VA.

NCT ID: NCT02696564 Not yet recruiting - Emphysema Clinical Trials

Losartan Effects on Emphysema Progression

LEEP
Start date: November 2016
Phase: Phase 4
Study type: Interventional

A randomized, parallel, placebo controlled trial to evaluate the effect of 100mg/day losartan on the progression of emphysema as measured by quantitative HRCT compared to placebo

NCT ID: NCT02687997 Recruiting - Lung Cancer Clinical Trials

Prevalence of Sleep Disordered Breathing in a Lung Cancer Screening Cohort

SAILS
Start date: February 2016
Phase: N/A
Study type: Interventional

Prospective study of sleep disordered breathing in a lung cancer screening cohort.

NCT ID: NCT02682147 Not yet recruiting - Emphysema Clinical Trials

Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema

Start date: March 2016
Phase: N/A
Study type: Interventional

This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. The investigators will correlate DECT measures of perfusion with lung injury measured by single photon emission computed tomography (SPECT). The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema

NCT ID: NCT02627872 Active, not recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease

COSMIC
Start date: March 2007
Phase: N/A
Study type: Observational

Chronic Obstructive Pulmonary Disease (COPD) is an increasing global health problem, which primarily increases among the female population. The purpose of this study is to perform in-depth clinical and molecular characterizations of early stage COPD patients, as well as healthy never-smoker and at-risk smoking control populations to identify molecularly related subgroups patients, including gender-related sub-phenotypes of COPD.