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Emphysema clinical trials

View clinical trials related to Emphysema.

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NCT ID: NCT02778802 Not yet recruiting - Clinical trials for Pulmonary Hypertension

Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR

Start date: June 2016
Phase: N/A
Study type: Observational

This study is designed as a prospective study, with the primary endpoint being changes in pulmonary hemodynamic parameters after ELVR in patients with severe emphysema. Secondary endpoints will be changes in lung function parameters, exercise capacity, and QoL.

NCT ID: NCT02719184 Recruiting - Clinical trials for Pulmonary Disease, Chronic Obstructive

Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)

Start date: April 2016
Phase: N/A
Study type: Observational

The study will include 125 healthy subjects (ex-smoker without any airflow limitation), 125 COPD GOLD (global initiative for chronic obstructive lung disease) I , 125 COPD GOLD II, 125 COPD GOLD III and up to 40 (with a minimum of 20) patients with COPD and A1AT (Alpha1-Antitrypsin) deficiency (ZZ genotype). Soluble and imaging biomarkers will be investigated addressing different aspects of disease pathways postulated to be relevant for COPD progression.

NCT ID: NCT02713347 Not yet recruiting - Heart Failure Clinical Trials

Advancing Symptom Alleviation With Palliative Treatment

ADAPT
Start date: June 2016
Phase: Phase 3
Study type: Interventional

Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are common serious illnesses. Despite disease-specific medical care for CHF and COPD, people with either illness are often left with poor quality of life (i.e., burdensome symptoms, impaired function). Furthermore, while CHF and COPD are leading causes of hospitalization and mortality, few people with either illness engage in advance care planning, the process of considering and communicating healthcare values and goals. The investigators are conducting a randomized clinical trial to study a symptom management, psychosocial care and advance care planning intervention to improve quality of life. The study is important because it aims to improve quality of life and provision of care according to peoples' goals and preferences in common, burdensome illnesses. Furthermore, this study will generate information that supports the broader dissemination and implementation of the intervention and informs the development of future palliative care and team-based interventions in the VA.

NCT ID: NCT02696564 Not yet recruiting - Emphysema Clinical Trials

Losartan Effects on Emphysema Progression

LEEP
Start date: May 2016
Phase: Phase 4
Study type: Interventional

A randomized, parallel, placebo controlled trial to evaluate the effect of 100mg/day losartan on the progression of emphysema as measured by quantitative HRCT compared to placebo

NCT ID: NCT02687997 Recruiting - Lung Cancer Clinical Trials

Prevalence of Sleep Disordered Breathing in a Lung Cancer Screening Cohort

SAILS
Start date: February 2016
Phase: N/A
Study type: Interventional

Prospective study of sleep disordered breathing in a lung cancer screening cohort.

NCT ID: NCT02682147 Not yet recruiting - Emphysema Clinical Trials

Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema

Start date: March 2016
Phase: N/A
Study type: Interventional

This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking population. The investigators will correlate DECT measures of perfusion with lung injury measured by single photon emission computed tomography (SPECT). The investigators will study the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent lung injury in smokers that are susceptible to emphysema

NCT ID: NCT02627872 Active, not recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease

COSMIC
Start date: March 2007
Phase: N/A
Study type: Observational

Chronic Obstructive Pulmonary Disease (COPD) is an increasing global health problem, which primarily increases among the female population. The purpose of this study is to perform in-depth clinical and molecular characterizations of early stage COPD patients, as well as healthy never-smoker and at-risk smoking control populations to identify molecularly related subgroups patients, including gender-related sub-phenotypes of COPD.

NCT ID: NCT02611947 Completed - Healthy Clinical Trials

CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight

Start date: October 2010
Phase: N/A
Study type: Observational

Various indexes have been proposed to quantify both pulmonary emphysema and airways disease on chest CT scans. It is unknown whether these indexes should be consider in absolute values or as compared to predicted normal values. The purposes of the present study is thus : a) to measure these indexes at CT in healthy volunteers; b) to investigate their relations with gender, height and weight.

NCT ID: NCT02556697 Recruiting - Pulmonary Disease Clinical Trials

In Vivo Endomicroscopic Description of Pulmonary Microcirculation in Systemic Sclerosis and Emphysema Patients

MiPECSE
Start date: December 2014
Phase: N/A
Study type: Interventional

Systemic sclerosis (SSc) is a generalized disorder of connective tissue, arterioles and microvessels, characterized by the occurrence of fibrosis and vascular obliteration phenomena. The alterations in lung microvessels are found in pulmonary involvement of scleroderma, which are the most serious complications of the disease. In pulmonary emphysema, there are also changes in pulmonary microvasculature, which are involved in the onset and development of the disease. The confocal endomicroscopy is an endoscopic technique which can be performed during a bronchoscopy. This technique makes it possible to observe in real time the most distal pulmonary elements at the microscopic scale. After injection of fluorescein, then the technique of observing the pulmonary microvasculature, in vivo and in situ. The characterization of microvascular lesions in these two pathologies could improve understanding of their mechanisms and ultimately improve the early management of patients.

NCT ID: NCT02499380 Recruiting - Emphysema Clinical Trials

Changes in Lung Physiology and Cardiac Performance in Patients With Emphysema Post Bilateral RePneu Coil Treatment

Start date: June 2015
Phase: N/A
Study type: Observational

The objective of this post-marketing study is to advance the understanding of the mechanism of action of the CE marked RePneu Coil by observing changes in lung physiology and cardiac performance in patients with emphysema treated with the RePneu Coils, when used as intended.