| Eligibility |
Inclusion Criteria:
1. Aged 18 to 75 years, inclusive at Visit 1 Screen.
2. Clinical diagnosis of functional diarrhea or IBS with diarrhea according to Rome III
or IV criteria at Visit 1 Screen.
3. Clinical laboratory evidence of BAM (20-22), with at least one of the following
results recorded in their past medical history:
- Serum C4 = 52 ng/mL
- Fecal BA > 2337 µmoles / 48 hours
- Total fecal BA > 1000 µmoles / 48 hours + 4 % primary BA
- Fecal primary BA > 10% / 48 hours
4. Body mass index (BMI) 18.0 to 45.0 kg/m2, inclusive at Visit 1 Screen
5. Understands the study procedures, is willing and able to comply with the study
procedures, and is able to give informed consent
6. If treated with any of the following medications, dosing must be stable for 30 days
prior to Visit 1 Screen. Patient must agree to maintain the same dose of medication
throughout the study:
- Tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs),
serotonin and norepinephrine reuptake inhibitors (SNRIs).
- Bile acid sequestrants such as colestipol, cholestyramine and colesevelam.
7. Participants must use one highly effective method of contraception for 30 days before
the study through 90 days after study completion for males and through 30 days after
study completion for females. Highly effective methods of contraception include: Oral,
implantable, transdermal or injectable hormonal contraceptives; standard intrauterine
device or vaginal ring; Male or female condoms and diaphragms used with spermicide;
abstinence from heterosexual intercourse; female partners exclusively sexually active
with a surgically sterilized male partner. Females who are surgically sterile having
experienced a prior hysterectomy, bilateral salpingectomy, or bilateral oophorectomy
or postmenopausal (defined as12 consecutive months with no menses) are not considered
to be of childbearing potential.
Exclusion Criteria:
1. Pregnant or lactating
2. Structural or metabolic diseases/conditions that affect the gastrointestinal system
3. Use of the following medications at least 14 days prior to Visit 1 throughout the
duration of the treatment period
- Patients may elect to withdraw from bile acid sequestrants such as colestipol,
cholestyramine and colesevelam or they may continue but they must continue at the
same dose throughout the study.
- GI medications including:
- Anti-nausea agents including trimethobenzamide, promethazine, prochlorperazine,
dimenhydrinate, hydroxyzine
- Osmotic laxative agents including lactulose, sorbitol or PEG solutions as Miralax
and Glycolax
- Prokinetic agents including tegaserod, metoclopramide, prucalopride, domperidone,
erythromycin, clarithromycin and azithromycin.
- 5-HT3 antagonists including alosetron, ondansetron, tropisetron
- Drugs with a known pharmacological activity at 5-HT4, 5-HT2b or 5-HT3 receptors
including tegaserod, ondansetron, granisetron and tropisetron
- All narcotics including codeine, morphine, and propoxyphene, either alone or in
combination
- Anti-cholinergics including dicyclomine, hyoscyamine, propantheline.
- Antimuscarinics
- Tramadol
- Peppermint oil
- Systemic antibiotics and antibiotics directed at colonic flora including
rifaximin and metronidazole
4. Use of CNS stimulant medications, including methylphenidate, atomoxetine, modafinil,
amphetamines or phentermine.
5. Clinically relevant changes in dietary, lifestyle, or exercise regimen within 30 days
prior to Visit 1 Screen and throughout the duration of the study
6. Any colonic or major abdominal surgery including bariatric surgery, gastric banding,
stomach surgery and intestinal or colonic surgery. Procedures such as appendectomy,
cholecystectomy, hysterectomy, caesarean section, or polypectomy are allowed as long
as they have occurred at least 3 months prior to Visit 1 Screen.
7. .History of colorectal cancer, inflammatory bowel disease, diverticulitis, ischemic
colitis, microscopic colitis or celiac disease
8. History of organic abnormalities of the GI tract, intestinal obstruction, stricture,
toxic megacolon, GI perforation, or impaired intestinal circulation.
9. Other GI diseases such as GI bleeding or ulcerations
10. History of cerebrovascular disease including stroke, TIA, acute coronary syndrome,
myocardial infarction or unstable angina
11. Clinically significant cardiac history or presence of electrocardiogram (ECG) findings
at Visit 1 Screen:
- Abnormal heart rate < 40 or > 100 beats per minute
- QTc interval > 470 milliseconds (ms)
- QRS interval = 110 ms
- PR interval = 220 ms
12. Hepatic dysfunction including abnormal serum alanine aminotransferase [ALT] or
aspartate transaminase [AST] > 3 × upper limit of normal [ULN]); total direct
bilirubin > 2 × ULN, or alkaline phosphatase > 2 × ULN at Visit 1 Screen
13. Clinically significant renal insufficiency including serum creatinine > 2.5 mg/dL at
Visit 1 Screen
14. History of severe head injury or history of seizures
15. History of suicide attempt or a hospitalization for a major psychiatric condition
within 1 year prior to Visit 1 Screen. At Visit 1 Screen or during the optional remote
consent and eligibility review, participants will complete the Hospital Anxiety and
Depression questionnaire. If either score for anxiety or depression individually
exceeds 8, the score will be discussed. The patient will be and advised whether to
participate or whether to see their primary care physician.
16. History of alcohol use disorder or substance use disorder within 2 years of Visit 1
Screen.
17. Significant history or clinical manifestation of any endocrine, allergic,
dermatological, hepatic, renal, hematological, pulmonary, GI, neurological or
psychiatric disorder, malignancy (with the exception of treated basal cell
carcinomas), or any other condition that would prevent the individual from
participating in the study due to risk to the scientific validity of study assessments
or to personal well-being of the patient.
18. Participated in another clinical study that includes an investigational drug or a
biologic therapy within 30 days or 5 half-lives, whichever time period is longer,
prior to Visit 1 Screen.
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