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NCT04212182 Clinical Trial

The Physiological Effect of High Flow Oxygen Therapy

Acute Exacerbation of Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
The Physiological Effect of High Flow Oxygen Therapy on Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04212182
Other study ID # GIRH-HFNC8306
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date December 27, 2019
Est. completion date July 1, 2020

Study information
Verified date December 2019
Source The First Affiliated Hospital of Guangzhou Medical University
Contact Lili Guan, PhD
Phone +8613422288665
Email dr_nickguan@163.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or do not benefit from it. High-flow nasal cannula (HFNC) is well tolerated and may be used to patients with AECOPD who are intolerant to NPPV treatment. This study is to evaluate the physiological effect of HFNC and compare it with NPPV.

Recruitment information / eligibility
Status Recruiting
Enrollment 10
Est. completion date July 1, 2020
Est. primary completion date July 1, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- AECOPD patients with acute hypercapnic respiratory failure

Exclusion Criteria:

- other lung/pleural diseases or thoracic deformity

- severe heart failure (New York Heart Association class IV), severe dysrhythmia

- unstable angina, or malignant comorbidity

- obesity (BMI = 35 kg/m²)

- severe obstructive sleep apnea syndrome

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• HFNC
HFNC provides warmed and humidified gas administered through slightly enlarged nasal prongs.
• NPPV
NPPV is the standard therapy for ventilatory failure in AECOPD.

Locations
Country Name City State
China The First Affiliated Hospital of Guangzhou Medical University. Guangzhou Guangdong

Sponsors (1)
Lead Sponsor Collaborator
The First Affiliated Hospital of Guangzhou Medical University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Neural respiratory drive Neural respiratory drive is calculated by diaphragm electromyogram 30 minutes
Secondary Work of breathing Work of breathing is calculated by the transdiaphragmatic pressure 30 minutes
Secondary Transcutaneous CO2 Transcutaneous CO2 is a non-invasive method estimated the partial pressure of arterial blood CO2. 30 minutes
See also
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Recruiting NCT04259736 - Prospective Cohort Study of Molecular Mechanism of Lower Respiratory Tract Microbes in Patients With AECOPD
Completed NCT03633838 - Clinical Outcome of Corticosteroids in the Treatment of COPD Exacerbations in China
Completed NCT02051166 - Clinical Practice of AECOPD Management in China N/A
Recruiting NCT04101500 - Effect of Compound Sodium Chlorate and Aminophylline Tablets on Chronic Obstructive Pulmonary Disease(COPD). Phase 4