Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Nasal High Flow Versus Non-Invasive Ventilation in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Although non-invasive ventilation (NIV) usage has increased significantly over time in COPD
exacerbation, a great percentage of patients (~30%) present contraindications to NIV or
cannot tolerate it. Nasal high flow (NHF) has been introduced for the management of hypoxemic
respiratory failure in adults with favorable effects on ventilation and respiratory
mechanics. The above mentioned NHF positive effects has been observed also in stable COPD
patients with or without chronic hypercapnia.
In this study, the investigators hypothesize that NHF is not inferior to NIV for respiratory
support in patients with COPD exacerbation and acute or acute on chronic hypercapnic
respiratory failure.
The use of non-invasive ventilation (NIV) in COPD exacerbation has increased significantly
over time since it has been shown to improve acute respiratory acidosis (increases pH and
decreases PaCO2), decrease respiratory rate, work of breathing, severity of breathlessness
and therefore reduce mortality and intubation rates.
Despite all these favorable effect, a great percentage of patients (~30%) present
contraindications to NIV or cannot tolerate it increasing thus the possibility of NIV failure
and consequently intubation rates.
Over the past decade, nasal high flow (NHF) oxygen therapy has been introduced for the
management of hypoxemic respiratory failure in adults. NHF can generate high flow rates up to
60 L·min−1 and through this mechanism exerts its positive effects on respiratory mechanics,
carbon dioxide washout, patient's respiratory rate and work of breathing. Although the above
mentioned NHF positive effects has been observed also in stable COPD patients with or without
chronic hypercapnia, NHF use in COPD exacerbation is questionable and only a few case reports
studies have been published showing favorable effects of NHF on COPD exacerbation.
In this study, the investigators hypothesize that NHF is not inferior to NIV for respiratory
support in patients with COPD exacerbation and acute or acute on chronic hypercapnic
respiratory failure.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05102305 -
A Multi-center,Prospective, OS to Evaluate the Effectiveness of 'NAC' Nebulizer Therapy in COPD (NEWEST)
|
||
| Completed |
NCT01867762 -
An Effectiveness and Safety Study of Inhaled JNJ 49095397 (RV568) in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
|
Phase 2 | |
| Recruiting |
NCT05562037 -
Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
|
N/A | |
| Terminated |
NCT04921332 -
Bright Light Therapy for Depression Symptoms in Adults With Cystic Fibrosis (CF) and COPD
|
N/A | |
| Completed |
NCT03089515 -
Small Airway Chronic Obstructive Disease Syndrome Following Exposure to WTC Dust
|
N/A | |
| Completed |
NCT02787863 -
Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology
|
Phase 4 | |
| Recruiting |
NCT05552833 -
Pulmonary Adaptive Responses to HIIT in COPD
|
N/A | |
| Recruiting |
NCT05835492 -
A Pragmatic Real-world Multicentre Observational Research Study to Explore the Clinical and Health Economic Impact of myCOPD
|
||
| Recruiting |
NCT05631132 -
May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases?
|
N/A | |
| Completed |
NCT03244137 -
Effects of Pulmonary Rehabilitation on Cognitive Function in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease
|
||
| Not yet recruiting |
NCT03282526 -
Volume Parameters vs Flow Parameters in Assessment of Reversibility in Chronic Obstructive Pulmonary Disease
|
N/A | |
| Completed |
NCT02546700 -
A Study to Evaluate Safety and Efficacy of Lebrikizumab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
|
Phase 2 | |
| Withdrawn |
NCT04446637 -
Acute Bronchodilator Effects of Ipratropium/Levosalbutamol 20/50 mcg Fixed Dose Combination vs Salbutamol 100 mcg Inhaler Plus Ipratropium 20 mcg Inhalation Aerosol Free Combination in Patients With Stable COPD
|
Phase 3 | |
| Completed |
NCT04535986 -
A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD
|
Phase 3 | |
| Recruiting |
NCT05865184 -
Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF or COPD
|
||
| Completed |
NCT03256695 -
Evaluate the Relationship Between Use of Albuterol Multidose Dry Powder Inhaler With an eModule (eMDPI) and Exacerbations in Participants With Chronic Obstructive Pulmonary Disease (COPD)
|
Phase 3 | |
| Completed |
NCT03295474 -
Telemonitoring in Pulmonary Rehabilitation: Feasibility and Acceptability of a Remote Pulse Oxymetry System.
|
||
| Withdrawn |
NCT04042168 -
Implications of Appropriate Use of Inhalers in Chronic Obstructive Pulmonary Disease (COPD)
|
Phase 4 | |
| Completed |
NCT03414541 -
Safety And Efficacy Study Of Orally Administered DS102 In Patients With Chronic Obstructive Pulmonary Disease
|
Phase 2 | |
| Completed |
NCT02552160 -
DETECT-Register DocumEnTation and Evaluation of a COPD Combination Therapy
|