Chronic Thromboembolic Pulmonary Hypertension Clinical Trial
— MVDOfficial title:
The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging
Verified date | January 2020 |
Source | Centre Chirurgical Marie Lannelongue |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Chronically elevated pulmonary pressures do not immediately result in right ventricular failure. During the initial period of exposure, the RV adapts to the increased afterload by altering its metabolism and morphology so as to meet the increased work requirement. Several, interconnected adaptive mechanisms have been proposed, including myocyte hypertrophy, a switch in the primary fuel used for ATP generation, increased angiogenesis, and decreased production of mitochondrial reactive oxygen species. While adaptation is initially successful in many cases, it is temporary, and after an uncertain period of time, the ventricle begins to fail. This transition from a compensated to decompensated state is difficult to predict clinically, and patients with different etiologies of CPOS progress to overt RV failure over significantly different time periods. This variability hinders the implementation of treatments that are tailored to a specific disease stage.
Status | Completed |
Enrollment | 20 |
Est. completion date | October 20, 2018 |
Est. primary completion date | November 20, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
-Inclusion Criteria: Chronic thromboembolic pulmonary hypertension group: - Patients undergoing pulmonary endarterectomy at Marie Lannelongue Surgical Center for the treatment of chronic thromboembolic pulmonary hypertension. Control group: - Patients undergoing adult cardiac surgery without evidence of pulmonary hypertension on preoperative assessment - Exclusion Criteria: Chronic thromboembolic pulmonary hypertension group: - Insufficient biopsy material, - pre-operative therapy with bosentan or sildenafil Control group: - Insufficient biopsy sample, - ischemic cardiomyopathy, - miral or tricuspid valve disease, - pre-operative pulmonary hypertension. |
Country | Name | City | State |
---|---|---|---|
France | Centre Chirurgical Marie Lannelongue | Le Plessis-Robinson |
Lead Sponsor | Collaborator |
---|---|
Centre Chirurgical Marie Lannelongue |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | relationship between the metabolic, morphologic and functional alterations in the right ventricle | to investigate the relationship between the metabolic, morphologic and functional alterations in the right ventricle before surgery,one and six months after surgery. | ||
Secondary | validation in human subjects of metabolic signaling pathway alterations found in animal model | analyse gene and protein expression during surgery |
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