Type 2 Diabetes Mellitus With Periodontal Disease Clinical Trial
Official title:
Disease Periodontal Influence on Markers of Cardiovascular in Diabetes Mellitus Patients
Verified date | November 2018 |
Source | Universidade Estadual Paulista Júlio de Mesquita Filho |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Periodontal disease (PD) and diabetes mellitus type 2 (DM2) have the same inflammatory etiopathogenesis and demonstrate a bidirectional relationship, for DM2 affects the severity of PD, and this may contribute to the overall inflammatory burden of the individual, influencing the natural course DM2. The aim of this study is to establish whether individuals with DM with or without chronic periodontitis have an increase in oxLDL and what is the influence of periodontal treatment in the reduction of oxLDL with consequent improvement in Diabetes Mellitus parameters.
Status | Completed |
Enrollment | 44 |
Est. completion date | January 28, 2017 |
Est. primary completion date | August 26, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 35 Years and older |
Eligibility |
Inclusion Criteria: - individuals older than 35 years with DM2 diagnosed for more than five years and HbA1c between 7% and 11%; - be diagnosed with generalized chronic periodontitis: present at least 6 sites with periodontal pocket and loss of insertion above 5mm and two more bags with loss of insertion above 6mm; - present at least 20 teeth; - agree to participate in the study and sign the informed consent form Exclusion Criteria: - patients with cardiovascular diseases, cancer, gastrointestinal disorders, skin diseases, pregnancy, lactation, smoking, arthritis, lupus or other diseases of inflammatory origin; - have undergone periodontal treatment in the last 12 months; - have made use of antioxidant supplements, anti-inflammatories, or antibiotics within the previous 3 months; - make use of medications that can alter the marking and concentration of oxLDL, for example, statins; - have changed the medication for glycemic control in the last 3 months; - present dental elements with pulpal or periapical inflammation. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Universidade Estadual Paulista Júlio de Mesquita Filho | LabviVale -Laboratory of clinical analyzes of Hospital viValle |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Probing depth change | The change in the probing depth will be measure in millimeters before and after the treatment. | baseline, 90 and 180 days | |
Secondary | oxLDL concentration Change | Change in concentration of oxLDL will be measured before and treatment. | baseline and 180 days | |
Secondary | LDL, HDL, Total cholesterol, Triacylglycerol | Blood concentration (g/ml) will be measured before and after periodontal therapy. | baseline and 180 days | |
Secondary | Plaque index | Number of teeth affected before and after periodontal treatment | baseline, 90 and 180 days | |
Secondary | Gingival index | number of teeth affected before and after periodontal treatment | baseline, 90 and 180 days | |
Secondary | Gingival Recession | Evaluated in millimeters before and after the treatment. | baseline, 90 and 180 days | |
Secondary | Clinical Attachment Level | Evaluated in millimeters before and after the treatment. | baseline, 90 and 180 days |