Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Is Chronic Obstructive Pulmonary Disease a Risk Factor for Cardiovascular Disease?
Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary atherosclerosis and other cardiac markers independent of conventional cardiovascular risk factors. The study is designed as a retrospective matched case-control study with follow-up via telephone interview.
Patients with chronic obstructive pulmonary disease (COPD) suffer from significant
cardiovascular morbidity and mortality. Coronary artery disease has often been linked
causally to COPD, but the exact pathophysiological mechanisms underpinning this association
remain speculative. A retrospective case-control study matching COPD patients and controls
one to one for smoking history and conventional cardiovascular risk factors will be
performed to study the association between COPD and cardiovascular outcomes. Filling in this
knowledge gap may contribute to the understanding of the interplay between COPD and
cardiovascular disease.
The objective of this retrospective case-control study is to determine whether COPD might be
a risk factor for coronary atherosclerosis, impaired left ventricular ejection fraction, and
major adverse cardiovascular events independent of conventional cardiovascular risk factors.
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Observational Model: Case Control, Time Perspective: Retrospective
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