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Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

Opioid Use Disorder Clinical Trial

Official title:
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment - A Pragmatic Hybrid Effectiveness/Implementation Trial

Clinical Trial Summary

The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors influencing the implementation of office-based methadone.

Clinical Trial Description

This study is a randomized, pragmatic hybrid type 1 effectiveness/implementation multisite (approximately 6 sites) trial to determine whether office-based methadone with pharmacy administration and/or dispensing or buprenorphine (BUP) results in greater treatment retention in approximately 600 patients with opioid use disorder (OUD). This trial will also identify implementation barriers, facilitators and acceptability at the patient, provider and health-systems level for office-based methadone with pharmacy administration and/or dispensing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06323824
Study type Interventional
Source Yale University
Contact Jessica Research Associate
Phone 203-785-6821
Email j.mckenzie@yale.edu
Status Not yet recruiting
Phase Phase 4
Start date May 2024
Completion date May 2029
View Details
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