Cannabidiol for Opioid Addiction

Status Recruiting

Clinical Trial Summary

The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD). The first phase of our project was an open cross-over design study in healthy individuals to confirm the safety and pharmacokinetic (PK) effects of CBD. This next phase is to determine whether CBD can serve as a potential adjunct treatment to reduce craving and anxiety in individuals with OUD maintained on opioid agonist therapy.

Clinical Trial Description

In this Phase 2 study, the research team will conduct a double-blind (placebo-controlled) randomized controlled trial to evaluate whether 200mg and/or 400mg CBD (BSPG Laboratories) given twice daily (morning and evening), as compared to placebo, reduces cue-induced craving and anxiety in individuals with opioid use disorder who are maintained on methadone or buprenorphine. In addition to in-lab physiological and behavioral assessments of cue-induced craving and anxiety, the research team will also employ ecological momentary assessment to obtain real-world measures of symptoms including craving, anxiety, and mood. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06206291
Study type	Interventional
Source	Icahn School of Medicine at Mount Sinai
Contact	Ruthie Perez
Phone	212-585-4696
Email	ruthie.perez@mssm.edu
Status	Recruiting
Phase	Phase 2
Start date	October 4, 2023
Completion date	October 2024

View Details

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