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Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF

Obstructive Sleep Apnea Clinical Trial

Official title:
Effect of Continuous Positive Airway Pressure (CPAP) on Abnormal Gastroesophageal Reflux and Lung Inflammation in Idiopathic Pulmonary Fibrosis (IPF)

Clinical Trial Summary

This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.

Clinical Trial Description

Participants in this study will have an overnight sleep study done while wearing a 24 hour pH monitor in the esophagus. If the participant has sleep apnea, he or she will be randomly assigned to receive either CPAP treatment or no CPAP treatment. After 4-8 weeks, the participant will have another overnight sleep study with 24 hour pH monitoring. Blood will also be collected at both time points and again after 6 months to measure biomarkers that are related to lung inflammation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05359965
Study type Interventional
Source University of Arizona
Contact Sachin Chaudhary, MD
Phone 520-621-4368
Email sachin@deptofmed.arizona.edu
Status Recruiting
Phase N/A
Start date October 1, 2019
Completion date March 1, 2025
View Details
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